3-Deazaneplanocin A

• Catalog number
  2060-250
• Price
  Please ask
• Size
  250 ug

• Alternative_name
  DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol
• Description
  A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
• CAS Number
  102052-95-9
• Structure Available
  Yes
• Molecular Formula
  C₁₂H₁₄N₄O₃
• Molecular Weight
  262.26
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (20 mg/ml) or EtOH (1 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A lysine methyltransferase EZH2 (KMT63) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD12545899
• PubChem CID
  73087
• PubChem CID Link
• SMILES
  C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N
• InChi
  InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11 (8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
• InChi Key
  OMKHWTRUYNAGFG-IEBDPFPHSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  3-Deazaneplanocin  
• Short name
  3-Deazaneplanocin A
• Alternative name
  3-Deazaneplanocin A

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