3-Deazaneplanocin A hydrochloride

• Catalog number
  2444-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride
• Description
  A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
• CAS Number
  120964-45-6
• Structure Available
  Yes
• Molecular Formula
  C₁₂H₁₄N₄O₃. HCl
• Molecular Weight
  298.73
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  H₂O (~5 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A lysine methyltransferase EZH2 (KMT63) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD18782644
• PubChem CID
  358176
• PubChem CID Link
• SMILES
  C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl
• InChi
  InChI=1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H
• InChi Key
  UNSKMHKAFPRFTI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  3-Deazaneplanocin   hydrochloride  
• Short name
  3-Deazaneplanocin A hydrochloride
• Alternative name
  3-Deazaneplanocin A hydrochloride

Product images

Similar products