VEGI/TL1 human recombinant

• Catalog number
  4966-1000
• Price
  Please ask
• Size
  1 mg

• Synonyms
  Tumor necrosis factor ligand superfamily member 15, TNFSF-15, TNFSF15, TNF ligand-related molecule 1, VEGI, TL-1, TL1, TL1A, VEGI192A, VEGI-192, MGC129934, MGC129935.
• Alternative_names
  Tumor necrosis factor ligand superfamily member 15, TNFSF-15, TNFSF15, TNF ligand-related molecule 1, VEGI, TL-1, TL1, TL1A, VEGI192A, VEGI-192, MGC129934, MGC129935, Vascular endothelial cell growth inhibitor.
• Description
  An anti-angiogenic protein
• Recombinant
  Yes
• Source
  E. coli
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Purity
  ≥95%
• Biological activity
  The ED₅₀ as determined by the dose-dependent inhibition of the proliferation of HUVEC is
• Molecular Weight
  21.8 kDa
• Storage Temp
  -20°C
• Shipping
  Blue ice
• Shelf Life
  12 months
• Appearance
  Lyophilized protein
• Physical form description
  Sterile filtered and lyophilized from a solution containing 0.5 M NaCl, 50 mM Tris-HCl, pH 7.5.
• Reconstitution Instructions
  Reconstitute in H₂O to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other aqueous buffers
• Background Information
  VEGI (Vascular Endothelial Growth Inhibitor) is a member of the tumor necrosis factor family. VEGI is predominantly an endothelial cell-specific gene, and recombinant VEGI is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. VEGI exerts two activities of endothelial cells: early Gl arrest of G0/G1-cells responding to growth stimuli, and programmed cell death. VEGI is also able to regulate the expression of several important genes involved in angiogenesis. Human VEGF is a 21.8 kDa homodimeric protein consisting of 192 amino acid polypeptide chains.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  VEGI/TL1  
• Gene symbol
  TNFSF15, MT-TL1
• Short name
  VEGI/TL1 recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  VEGI/TL1 H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:11931
• Gene
  TNFSF15
• Long gene name
  TNF superfamily member 15
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 15
• Synonyms
  • TL1
  • VEGI
  • TL1A
  • VEGI192A
  • MGC129934
  • MGC129935
• Synonyms name
  • vascular endothelial cell growth inhibitor
  • TNF superfamily ligand TL1A
  • TNF ligand-related molecule 1
  • vascular endothelial growth inhibitor-192A
• GenBank acession
  • AF039390
• Locus
  9q32
• Discovery year
  1998-12-04
• Entrez gene record
  9966
• Pubmed identfication
  • 9434163
• RefSeq identity
  • NM_005118
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000021011

Gene info

• Identity
  HGNC:7490
• Gene
  MT-TL1
• Long gene name
  mitochondrially encoded tRNA-Leu (UUA/G) 1
• Synonyms gene
  • MTTL1
• Synonyms gene name
  • tRNA leucine 1 (UUA/G)
  • mitochondrially encoded tRNA leucine 1 (UUA/G)
• Synonyms
  • TRNL1
• Locus
  mitochondria
• Discovery year
  1989-10-12
• Entrez gene record
  4567
• Pubmed identfication
  • 7219534
• Classification
  • Mitochondrially encoded transfer RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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