VEGI/TL1 human recombinant
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Catalog number4966-1000
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PricePlease ask
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Size1 mg
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SynonymsTumor necrosis factor ligand superfamily member 15, TNFSF-15, TNFSF15, TNF ligand-related molecule 1, VEGI, TL-1, TL1, TL1A, VEGI192A, VEGI-192, MGC129934, MGC129935.
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Alternative_namesTumor necrosis factor ligand superfamily member 15, TNFSF-15, TNFSF15, TNF ligand-related molecule 1, VEGI, TL-1, TL1, TL1A, VEGI192A, VEGI-192, MGC129934, MGC129935, Vascular endothelial cell growth inhibitor.
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DescriptionAn anti-angiogenic protein
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Purity≥95%
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Biological activityThe ED₅₀ as determined by the dose-dependent inhibition of the proliferation of HUVEC is
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Molecular Weight21.8 kDa
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Storage Temp-20°C
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ShippingBlue ice
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Shelf Life12 months
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AppearanceLyophilized protein
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Physical form descriptionSterile filtered and lyophilized from a solution containing 0.5 M NaCl, 50 mM Tris-HCl, pH 7.5.
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Reconstitution InstructionsReconstitute in H₂O to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other aqueous buffers
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Background InformationVEGI (Vascular Endothelial Growth Inhibitor) is a member of the tumor necrosis factor family. VEGI is predominantly an endothelial cell-specific gene, and recombinant VEGI is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. VEGI exerts two activities of endothelial cells: early Gl arrest of G0/G1-cells responding to growth stimuli, and programmed cell death. VEGI is also able to regulate the expression of several important genes involved in angiogenesis. Human VEGF is a 21.8 kDa homodimeric protein consisting of 192 amino acid polypeptide chains.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolTNFSF15, MT-TL1
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Short nameVEGI/TL1 recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameVEGI/TL1 H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameTNF superfamily member 15
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Synonyms gene name
- tumor necrosis factor (ligand) superfamily, member 15
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-12-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemitochondrially encoded tRNA-Leu (UUA/G) 1
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Synonyms gene
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Synonyms gene name
- tRNA leucine 1 (UUA/G)
- mitochondrially encoded tRNA leucine 1 (UUA/G)
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Synonyms
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Locus
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Discovery year1989-10-12
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Entrez gene record
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Pubmed identfication
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Classification
- Mitochondrially encoded transfer RNAs
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data