Axitinib (AG-013736)

Alternative_name

AG-013736
Description

Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models and renal cell carcinoma (RCC) and several other tumor types.
CAS Number

319460-85-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₁₈N₄OS
Molecular Weight

386.47
Cell Permeable

Yes
Purity

≥99% by HPLC
Solubilities

DMSO (10 mM)
Handling

Protect from light and moisture
Tag Line

A PTK inhibitor
Storage Condition

-20°C
Shipping Condition

RT
Shelf Life

24months
MDL Number

MFCD09837898
PubChem CID

6450551
PubChem CID Link
SMILES

CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4
InChi

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25- 26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25, 26)/b12-9+
InChi Key

RITAVMQDGBJQJZ-FMIVXFBMSA-N
Data Sheet Link
MSDS Available

Yes