MAP2K6 Polyclonal Antibody

• Catalog number
  CAC07136
• Price
  Please ask
• Size
  50 μg

• Other name
  Dual specificity mitogen-activated protein kinase kinase 6,MAP kinase kinase 6,MAPKK 6,MAPK/ERK kinase 6,MEK 6,Stress-activated protein kinase kinase 3,SAPK kinase 3,SAPKK-3,SAPKK3,MAP2K6,MEK6, MKK6, PRKMK6,SKK3
• Immunogen
  Recombinant human Dual specificity mitogen-activated protein kinase kinase 6 protein (1-334AA)
• Verified reactivity
  Human
• Verified applications
  ELISA,WB. Recommended dilution:WB:1:500-2000
• Raised in
  Rabbit
• Clonality
  Polyclonal
• Protein number
  P52564
• Gene number
  Please refer to GenBank
• NCBI number
  Please refer to NCBI
• Purity
  Caprylic Acid Ammonium Sulfate Precipitation Purified
• Storage recommendation
  Aliquot and store at -20°C. Minimize freezing and thawing.
• Use before
  1 year
• Shipping requirements
  Blue ice
• Estimated production time
  3-7 business days
• Supplementary information
  Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
• Notes
  For research use only. Not for diagnostic procedures.
• Hyperlink
• Properties
  If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
• French translation
  anticorps

• Gene target
  MAP2K6  
• Gene symbol
  MAP2K6
• Short name
  MAP2K6 Polyclonal Antibody
• Technique
  Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Label
  Unconjugated
• Alternative name
  mitogen-activated protein kinase kinase 6 polyclonal (antibody to-)
• Alternative technique
  polyclonals, antibodies
• Alternative to gene target
  mitogen-activated protein kinase kinase 6, MAPKK6 and MEK6 and MKK6 and PRKMK6 and SAPKK-3 and SAPKK3, MAP2K6 and IDBG-66516 and ENSG00000108984 and 5608, transferase activity, nuclei, Map2k6 and IDBG-213977 and ENSMUSG00000020623 and 26399, MAP2K6 and IDBG-643571 and ENSBTAG00000001609 and 100849300,286883

Gene info

• Identity
  HGNC:6846
• Gene
  MAP2K6
• Long gene name
  mitogen-activated protein kinase kinase 6
• Synonyms gene
  • PRKMK6
• Synonyms
  • MEK6
  • MKK6
  • SAPKK3
  • MAPKK6
• Synonyms name
  • protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
• GenBank acession
  • U39064
• Locus
  17q24.3
• Discovery year
  1997-11-11
• Entrez gene record
  5608
• Pubmed identfication
  • 8621675
• RefSeq identity
  • NM_002758
• Classification
  • Mitogen-activated protein kinase kinases
• VEGA ID
  OTTHUMG00000180311

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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