Human CellExp™ VEGF-B, human recombinant

• Catalog number
  7230-10
• Price
  Please ask
• Size
  10 ug

• Synonyms
  VRF, VEGFL, VEGFB, VEGF-B
• Alternative_names
  VRF, VEGFL, VEGFB, VEGF-B
• Description
  Plays a role only in the maintenance of newly formed blood vessels during pathological conditions
• Recombinant
  Yes
• Source
  HEK 293 cells
• Purity by SDS PAGE
  ≥95%
• Assay
  SDS-PAGE
• Endotoxin Level
  < 0.1 ng/ug of protein (
• Molecular Weight
  The protein is fused with 6 × His tag at the C-terminus and has a calculated MW of 20.2 kDa. The predicted N-terminus is Arg 22. DTT-reduced Protein migrates as 15-18 kDa and 33-35 kDa due to glycosylation.
• Storage Temp
  -20°C
• Shipping
  Gel Pack
• Shelf Life
  12 months
• Appearance
  Lyophilized powder
• Physical form description
  Lyophilized from 0.22 um filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
• Reconstitution Instructions
  Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
• Background Information
  Vascular endothelial growth factor B (VEGFB) also known as VEGF-related factor (VRF), is a secreted O-glycosylated protein, which belongs to the PDGF/VEGF growth factor family. VEGFB is expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. VEGFB is growth factor for endothelial cells. VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B also plays an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CellExp™   VEGF-B  
• Gene symbol
  VEGFA, VEGFB, VEGFC, VEGFD, SNRPB, ORM2, ERAL1, OR1B1, SPIB, EXPH5
• Short name
  CellExp™ VEGF-B, recombinant
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Humans
• Alternative name
  H. sapiens CellExp™ VEGF-B, H. sapiens Rec.
• Alternative technique
  rec

Gene info

• Identity
  HGNC:12680
• Gene
  VEGFA
• Long gene name
  vascular endothelial growth factor A
• Synonyms gene
  • VEGF
• Synonyms gene name
  • vascular endothelial growth factor
• Synonyms
  • VEGF-A
  • VPF
• GenBank acession
  • AB021221
• Locus
  6p21.1
• Discovery year
  1994-01-10
• Entrez gene record
  7422
• Pubmed identfication
  • 8786112
• RefSeq identity
  • NM_001025366
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000014745
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:12681
• Gene
  VEGFB
• Long gene name
  vascular endothelial growth factor B
• Synonyms gene
  • VRF
• Synonyms
  • VEGFL
• GenBank acession
  • BC008818
• Locus
  11q13.1
• Discovery year
  1996-10-26
• Entrez gene record
  7423
• Pubmed identfication
  • 8637916
  • 8919691
• RefSeq identity
  • NM_003377
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000167813

Gene info

• Identity
  HGNC:12682
• Gene
  VEGFC
• Long gene name
  vascular endothelial growth factor C
• Synonyms
  • VRP
  • VEGF-C
• Synonyms name
  • vascular endothelial growth factor-related protein
• GenBank acession
  • BC035212
• Locus
  4q34.3
• Discovery year
  1996-10-26
• Entrez gene record
  7424
• Pubmed identfication
  • 8617204
• RefSeq identity
  • NM_005429
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000160734

Gene info

• Identity
  HGNC:3708
• Gene
  VEGFD
• Long gene name
  vascular endothelial growth factor D
• Synonyms gene
  • FIGF
• Synonyms gene name
  • c-fos induced growth factor (vascular endothelial growth factor D)
• Synonyms
  • VEGF-D
• GenBank acession
  • AJ000185
• Locus
  Xp22.2
• Discovery year
  1997-03-27
• Entrez gene record
  2277
• Pubmed identfication
  • 9479493
• RefSeq identity
  • NM_004469
• Classification
  • VEGF family
• VEGA ID
  OTTHUMG00000021175
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:11153
• Gene
  SNRPB
• Long gene name
  small nuclear ribonucleoprotein polypeptides B and B1
• Synonyms gene
  • SNRPB1
• Synonyms
  • COD
  • SmB/SmB'
  • Sm-B/B'
  • snRNP-B
• Locus
  20p13
• Discovery year
  1988-11-28
• Entrez gene record
  6628
• Pubmed identfication
  • 1376292
• Classification
  • Small nucleolar RNA protein coding host genes
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000031694

Gene info

• Identity
  HGNC:8499
• Gene
  ORM2
• Long gene name
  orosomucoid 2
• Synonyms
  • AGP-B
  • AGP-B'
  • AGP2
• Synonyms name
  • alpha-1-acid glycoprotein, type 2
• Locus
  9q32
• Discovery year
  1991-03-11
• Entrez gene record
  5005
• Pubmed identfication
  • 4711474
  • 2970990
• RefSeq identity
  • NM_000608
• Classification
  • Lipocalins
• VEGA ID
  OTTHUMG00000021014

Gene info

• Identity
  HGNC:3424
• Gene
  ERAL1
• Long gene name
  Era like 12S mitochondrial rRNA chaperone 1
• Synonyms gene name
  • Era (E. coli G-protein homolog)-like 1
  • Era G-protein-like 1 (E. coli)
  • Era-like 12S mitochondrial rRNA chaperone 1
• Synonyms
  • HERA-B
• GenBank acession
  • AF082657
• Locus
  17q11.2
• Discovery year
  1999-11-19
• Entrez gene record
  26284
• Pubmed identfication
  • 10945472
  • 20604745
• VEGA ID
  OTTHUMG00000132675

Gene info

• Identity
  HGNC:8181
• Gene
  OR1B1
• Long gene name
  olfactory receptor family 1 subfamily B member 1
• Synonyms gene name
  • olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene)
  • olfactory receptor family 1 subfamily B member 1 (gene/pseudogene)
• Synonyms
  • OR9-B
• GenBank acession
  • AC006313
• Locus
  9q33.2
• Discovery year
  1999-12-09
• Entrez gene record
  347169
• RefSeq identity
  • NM_001004450
• Classification
  • Olfactory receptors, family 1
• VEGA ID
  OTTHUMG00000020616

Gene info

• Identity
  HGNC:11242
• Gene
  SPIB
• Long gene name
  Spi-B transcription factor
• Synonyms gene name
  • Spi-B transcription factor (Spi-1/PU.1 related)
• Synonyms
  • SPI-B
• Locus
  19q13.33
• Discovery year
  1994-12-15
• Entrez gene record
  6689
• Pubmed identfication
  • 1406622
• RefSeq identity
  • NM_003121
• Classification
  • ETS transcription factor family
• VEGA ID
  OTTHUMG00000183039

Gene info

• Identity
  HGNC:30578
• Gene
  EXPH5
• Long gene name
  exophilin 5
• Synonyms
  • SLAC2-B
• Synonyms name
  • synaptotagmin-like homologue lacking C2 domains b
• Locus
  11q22.3
• Discovery year
  2005-10-04
• Entrez gene record
  23086
• Pubmed identfication
  • 9734811
  • 11773082
• RefSeq identity
  • NM_015065
• VEGA ID
  OTTHUMG00000166536

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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