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anti DNA Methyltransferase Antibody

anti DNA Methyltransferase Antibody is available 6 times from Biovision labs

6110-50 | anti-DNA Methyltransferase 1 (Clone 60B1220.1) Antibody size: DNA Methyltransferase 1 (Clone 60B1220.1) Antibody | 349.75 USD

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6112-50 | anti-DNA Methyltransferase 2 (Clone 102B1259.2) Antibody size: DNA Methyltransferase 2 (Clone 102B1259.2) Antibody | 349.75 USD

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6111-50 | anti-DNA Methyltransferase 2 Antibody size: DNA Methyltransferase 2 Antibody | 349.75 USD

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6115-50 | anti-DNA Methyltransferase 3a (Clone 64B1446) Antibody size: DNA Methyltransferase 3a (Clone 64B1446) Antibody | 349.75 USD

Catalog number 6115-50
Supplier Biovision
Price 349.75 USD
Size DNA Methyltransferase 3a (Clone 64B1446) Antibody
Target of this antibody: DNMT3A
Alternative names of antibody target: DNMT3, DNMT3A
Background information: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in embryonic stem (ES) cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of DNMT3b gene occur in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Antibody host: Mouse
Clonality of antibody: Monoclonal
Isotype: Mouse IgG1κ
Clone: 64B1446
This antibody reacts with: Human, mouse
Immunogene sequence: Recombinant mouse Dnmt3a expressed in bacteria. The epitope was found to be located near the C-terminus (amino acids 705-908).
Formulation of this antibody: 50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium azide.
Purification method: Protein G purified
This antibody has been succesfully tested for use in following methods: Western blot, Immunocytochemistry, Immunofluorescence, Chromatin Immunoprecipitation, Immunohistochemistry
Recommended usage: Western blot: 2 µg/ml, ICC/IF: 5 µg/ml, ChIP/IHC (paraffin embedded sections). However, the optimal conditions should be determined individually.
Gene targetDNA Methyltransferase 64B1446
Short name anti-DNA Methyltransferase 3a (Clone 64B1446) Antibody
Alternative name antibody to-Desoxyribonucleic acid Methyltransferase 3a (clonality 64B1446) (Antibody to)
Clone name 64B1446
1. Gene info
Identity 9413
Gene PRKDC
Long gene name protein kinase, DNA-activated, catalytic subunit
Synonyms gene
  • HYRC
  • HYRC1
Synonyms gene name
  • protein kinase, DNA-activated, catalytic polypeptide
Synonyms
  • DNPK1
  • p350
  • DNAPK
  • XRCC7
  • DNA-PKcs
  • DNAPKc
  • DNA-PKC
  • p460
Synonyms name
  • DNA-dependent protein kinase catalytic subunit
Locus 8q11.21
Discovery year 1993-11-09
Entrez gene record 5591
Pubmed identfication
  • 7638222
RefSeq identity
  • NM_001081640
Classification
  • Armadillo like helical domain containing
Havana BLAST/BLAT OTTHUMG00000164239
Locus Specific Databases
  • LRG_162
Product images
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6113-50 | anti-DNA Methyltransferase 3a (Clone 64B814.1) Antibody size: DNA Methyltransferase 3a (Clone 64B814.1) Antibody | 349.75 USD

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6114-50 | anti-DNA Methyltransferase 3b (Clone 52A1018) Antibody size: DNA Methyltransferase 3b (Clone 52A1018) Antibody | 349.75 USD

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Concentration of antibody: N/A
Form of antibody: Liquid
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Technique Antibody, anti, dna
Alternative technique antibodies
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anti-DNA Methyltransferase 3a (Clone 64B1446) Antibody | Tec
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • DNA
  • Methyltransferase
  • 60B1220.1
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