Rabbit Anti-Human ATR (pSer435 + pSer436) Polyclonal: ATTO 633
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Catalog numberSPC-918D-A633
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PricePlease ask
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Size100 µl
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ImmunogenA phospho-specific peptide corresponding to residues surrounding Ser435 and Ser436 of human ATR (AA432-439)
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Antibody s targetHuman ATR (pSer435 + pSer436)
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Antibody s full descriptionRabbit Anti-Human ATR (pSer435 + pSer436) Polyclonal
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Antibody s categoryPolyclonal Antibodies
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Antibody s other nameFRAP Related Protein 1 Antibody, MEC1 Antibody, RAC3 Antibody, SCKL Antibody
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Verified applicationsWB, AM
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Raised inRabbit
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Antibody s reactivityHuman
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Antibody s recommended dilutions for useWB (1:250); optimal dilutions for assays should be determined by the user.
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Antibody s purified fromPeptide Affinity Purified
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Recommended buffer for storagePBS pH7.4, 50% glycerol, 0.025% Thimerosal
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Antibody s concentrationSee included datasheet or contact our support service
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Antibody s specificityDetects 301.367 kDa.
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Storage recommendations-20°C
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Shipping recommendationsBlue Ice or 4°C
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Certificate of analysisA 1:250 dilution of SPC-918 was sufficient for detection of ATR (pSer435 + pSer436) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
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Antibody in cellNucleus, PML body
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Tissue specificityUbiquitous
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Scientific contextATR is a protein-serine/threonine kinase. It is part of the PI3K family and functions in a complex with ATRIP. It responds to DNA damage and replication stresses and activates proteins that mediate DNA repair such as p53, BRCA1 and more. It other roles involve checkpoint signalling by interacting with chk1, fragile site stabilty and regulation of centrosome duplication.
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BibliographyRefer to PubMed
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Released date29/Aug/2016
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NCBI numberNP_001175
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Gene number545
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Protein numberQ13535
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PubMed numberRefer to PubMed
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Tested applicationsTo be tested
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Tested reactivityTo be tested
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Antibody s datasheetContact our support service to receive datasheet or other technical documentation.
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Representative figure linkNo Data Available
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Warning informationNon-hazardous
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Country of productionCanada
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Total weight kg1.4
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Net weight g0.1
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Stock availabilitIn Stock
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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TestStressMark antibodies supplies antibodies that are for research of human proteins.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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GroupPolyclonals and antibodies
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AboutPolyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. Rabbits are used for polyclonal antibody production by StressMark antibodies. Rabbit antibodies are very stable and can be stored for several days at room temperature. StressMark antibodies adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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Gene target
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Gene symbolANTXR1, SERPINA2, ATR
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Short nameRabbit Anti- ATR (pSer435 + pSer436) Polyclonal: ATTO 633
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Techniqueanti-Human, Polyclonal, Rabbit, anti-, anti, antibody to, antibodies, antibodies against human proteins, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
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HostRabbit, Rabbits
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IsotypeImmunoglobulin
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LabelATTO 633
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SpeciesHuman, Humans
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Alternative nameproduction species: rabbit Antibody toHuman ataxia telangiectasia and Rad3 related (pSer435 + pSer436) polyclonal: ATTO 633
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Alternative techniquepolyclonals, rabbit-anti, antibodies
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Alternative to gene targetataxia telangiectasia and Rad3 related, FCTCS and FRP1 and MEC1 and SCKL and SCKL1, ATR and IDBG-59521 and ENSG00000175054 and 545, transferase activity, nuclei, Atr and IDBG-191646 and ENSMUSG00000032409 and 245000, ATR and IDBG-638174 and ENSBTAG00000011529 and 504869
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Gene info
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Identity
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Gene
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Long gene nameANTXR cell adhesion molecule 1
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Synonyms gene name
- anthrax toxin receptor 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-08-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameserpin family A member 2 (gene/pseudogene)
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Synonyms gene
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Synonyms gene name
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2, pseudogene
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Serpin peptidase inhibitors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameATR serine/threonine kinase
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Synonyms gene name
- ataxia telangiectasia and Rad3 related
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-04-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data