anti-Endoglin Antibody

• Catalog number
  49-773
• Price
  Please ask
• Size
  0.05 mL

• Gene info
  CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an Oand N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-β1 and Beta3 with high affinity but not TGF-β2. Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Endoglin has been shown to be a useful marker to identify tumor angiogenesis. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia.
• Gene names
  ENG, CD105, CD105 antigen, END, HHT1, ORW, ORW1, Osler-Rendu-Weber syndrome 1, Endoglin
• Antibodie s label
  unlabelled serum
• Purity
  Immunoaffinity Chromatography
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Spicific to
  Recognizes human CD105.
• Antigen
  Endoglin antibody was made against amino acids 26 - 176 of Endoglin (Human).
• Immuno application
  ELISA, immuno-histo-chemistry
• Antibody advice
  Endoglin antibody can be used in ELISA, and immunohistochemistry starting at 5 ug/mL.
• Suspention pH azide
  10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, before the addition of glycerol to 40%
• Keep at
  Endoglin antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.
• Works with
  Human
• Omim nr
  3041681
• Ncbi nr
  P17813
• Vial with antibody
  in solution
• NCBI GENE nr
  2022
• GENE symbol
  ENG
• Antigene name
  endoglin
• Source
  Homo sapiens
• Protein nr
  P17813
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Endoglin  
• Gene symbol
  ENG
• Short name
  anti-Endoglin Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toEndoglin (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3349
• Gene
  ENG
• Long gene name
  endoglin
• Synonyms gene
  • ORW1
  • ORW
• Synonyms gene name
  • Osler-Rendu-Weber syndrome 1
• Synonyms
  • END
  • HHT1
  • CD105
• GenBank acession
  • AF035753
• Locus
  9q34.11
• Discovery year
  1993-03-03
• Entrez gene record
  2022
• Pubmed identfication
  • 8404038
  • 10548503
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000020723
• Locus Specific Databases
  • Hereditary Hemorrhagic Telangiectasia (HHT) Mutation Database
  • LRG_589

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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