-
Category
Primary Antibodies
-
Long description
Human SET was originally identified as part of the SET-CAN fusion gene produced by a somatic translocation event in a patient with acute undifferentiated leukemia. In developing kidney, SET is highly expressed in the zone of nephron morphogenesis. SET has been shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. SET is also involved in the regulation of renal cell proliferation and tumorigenesis. SET mRNA expression is markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. High levels of SET mRNA and SET protein expression arefound in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma.
-
Antibody come from
Synthetic protein made to the N-terminal domain of human 5HT5A Receptor
-
Other description
Phosphate buffered saline containing 0.1% sodium azide. Ammonium Sulfate Precipitation
-
Clone
Polyclonal
-
Antigen antibody binding interaction
Rabbit anti SET antibody Phosphatase 2A Inhibitor I2PP2A Antibody
-
Antibody is raised in
Rabbit
-
Antibody s reacts with
Human
-
Antibody s reacts with these species
This antibody doesn't cross react with other species
-
Antibody s specificity
No Data Available
-
Application
Western Blot
-
Antibody s suited for
Antibody can be used at 5-10 µg/ml for immunohistochemistry (formalin-fixed paraffin embedded tissues). Optimal concentration should be evaluated by serial dilutions.
-
Storage
-20ºC
-
Relevant references
1. Doly, S., et al. '5-HT5A receptor localization in the rat spinal cord suggests a role in nociception and control of pelvic floor musculature.' J. Comp. Neurol. 2004, 30, 316-329_x000B__x000B_2. Wang, Z.Y., et al. '5-HT5a receptors in the carotid body chemoreception pathway of rat.' Neurosci. Lett. 2000, 278, 9-12_x000B__x000B_3. Garcia-Alcocer, G., et al. 'Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin treatment.' Neurosci. Lett. 2010, 486, 171-173._x000B__x000B_4. Yosifova, A., et al. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J. Affect Disord 2009, 117, 87-97_x000B__x000B_5. Schanen, N.C., et al. Assignment of the 5-hydroxytryptamine (serotonin) receptor 5A gene (HTR5A) to human chromosome band 7q36.1. Cytogenet. Cell. Genet. 1996, 72, 187-188
-
Protein number
see ncbi
-
Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Properties
If you buy Antibodies supplied by nordc they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
About
Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin name
Oryctolagus cuniculus
-
French translation
anticorps
