Anti-CREB-H/CREB3L3 (Polyclonal), ALEXA Fluor 594

• Catalog number
  GENTObs-11239R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  CREB-H/CREB3L3
• Specificity
  This antibody reacts specifically with CREB-H/CREB3L3
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  N/A
• Antigen Source
  KLH conjugated synthetic peptide derived from human CREB-H
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  IF(IHC-P)
• Applications with corresponding dilutions
  IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  cAMP responsive element binding protein 3 like 3; cAMP responsive element-binding protein 3 like protein 3; CREB H; CREB/ATF family transcription factor; CREBH; Cyclic AMP responsive element binding protein 3 like protein 3; cAMP-responsive element-binding protein 3-like protein 3; HYST1481; MGC126553; MGC126557; Transcription factor CREB H; CR3L3_HUMAN.
• Also known as
  CREB-H/CREB3L3 Polyclonal Antibody
• Other name
  Anti-CREB-H/CREB3L3 Polyclonal
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Group
  Polyclonals and antibodies
• About
  Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

• Gene target
  CREB-H/CREB3L3  
• Gene symbol
  CREB3L3, NCAPH, HLA-H, IGHV3-69-1, ATF4, FUT1, PIGH, NEFH, HFE, RAB11B
• Short name
  Anti-CREB-H/CREB3L3
• Technique
  Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  CREB-H/CREB3L3 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  polyclonals, antibodies

Gene info

• Identity
  HGNC:18855
• Gene
  CREB3L3
• Long gene name
  cAMP responsive element binding protein 3 like 3
• Synonyms
  • CREB-H
  • CREBH
• Synonyms name
  • cAMP-responsive element-binding protein, hepatic-specific
• Locus
  19p13.3
• Discovery year
  2003-12-09
• Entrez gene record
  84699
• Pubmed identfication
  • 11353085
• RefSeq identity
  • NM_032607
• Classification
  • CREB3 transcription factor family
• VEGA ID
  OTTHUMG00000181846

Gene info

• Identity
  HGNC:1112
• Gene
  NCAPH
• Long gene name
  non-SMC condensin I complex subunit H
• Synonyms gene
  • BRRN1
• Synonyms gene name
  • barren (Drosophila) homolog
  • barren homolog (Drosophila)
  • barren homolog 1 (Drosophila)
  • non-SMC condensin I complex, subunit H
• Synonyms
  • CAP-H
  • hCAP-H
• GenBank acession
  • BC024211
• Locus
  2q11.2
• Discovery year
  1998-02-11
• Entrez gene record
  23397
• Pubmed identfication
  • 9417923
• RefSeq identity
  • NM_015341
• Classification
  • Condensin I subunits
  • Kleisins
• VEGA ID
  OTTHUMG00000130451

Gene info

• Identity
  HGNC:4965
• Gene
  HLA-H
• Long gene name
  major histocompatibility complex, class I, H (pseudogene)
• GenBank acession
  • M31944
• Locus
  6p22.1
• Discovery year
  1991-08-01
• Entrez gene record
  3136
• Pubmed identfication
  • 1517564
  • 2294403
• RefSeq identity
  • NR_001434
• Classification
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031160
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:5631
• Gene
  IGHV3-69-1
• Long gene name
  immunoglobulin heavy variable 3-69-1 (pseudogene)
• Synonyms gene
  • IGHV3-H
• Synonyms gene name
  • immunoglobulin heavy variable 3-H (provisional)
  • immunoglobulin heavy variable 3-H pseudogene (provisional)
  • immunoglobulin heavy variable 3-H (pseudogene)
• Synonyms
  • IGHV3-h
• GenBank acession
  • AJ879484
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28402
• Pubmed identfication
  • 16133446
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000191145

Gene info

• Identity
  HGNC:786
• Gene
  ATF4
• Long gene name
  activating transcription factor 4
• Synonyms gene
  • TXREB
• Synonyms gene name
  • activating transcription factor 4 (tax-responsive enhancer element B67)
• Synonyms
  • TAXREB67
  • CREB-2
• Synonyms name
  • tax-responsive enhancer element B67
• GenBank acession
  • D90209
• Locus
  22q13.1
• Discovery year
  1992-06-09
• Entrez gene record
  468
• Pubmed identfication
  • 1847461
  • 1534408
• RefSeq identity
  • NM_001675
• Classification
  • Basic leucine zipper proteins
• VEGA ID
  OTTHUMG00000151099

Gene info

• Identity
  HGNC:4012
• Gene
  FUT1
• Long gene name
  fucosyltransferase 1 (H blood group)
• Synonyms gene
  • H
  • HSC
• Synonyms gene name
  • fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included)
  • fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
• Synonyms name
  • galactoside 2-alpha-L-fucosyltransferase
• Locus
  19q13.33
• Discovery year
  1989-06-06
• Entrez gene record
  2523
• RefSeq identity
  • NM_000148
• Classification
  • Fucosyltransferases
  • Blood group antigens
• VEGA ID
  OTTHUMG00000183325
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • LRG_810

Gene info

• Identity
  HGNC:8964
• Gene
  PIGH
• Long gene name
  phosphatidylinositol glycan anchor biosynthesis class H
• Synonyms gene name
  • phosphatidylinositol glycan, class H
• Synonyms
  • GPI-H
• Synonyms name
  • phosphatidylinositol N-acetylglucosaminyltransferase subunit
• Locus
  14q24.1
• Discovery year
  1994-09-06
• Entrez gene record
  5283
• Pubmed identfication
  • 8204896
• RefSeq identity
  • NM_004569
• Classification
  • Phosphatidylinositol glycan anchor biosynthesis
• VEGA ID
  OTTHUMG00000171806

Gene info

• Identity
  HGNC:7737
• Gene
  NEFH
• Long gene name
  neurofilament heavy chain
• Synonyms gene name
  • neurofilament, heavy polypeptide 200kDa
  • neurofilament heavy polypeptide
  • neurofilament heavy
• Synonyms
  • NF-H
  • NFH
• Locus
  22q12.2
• Discovery year
  1988-08-31
• Entrez gene record
  4744
• RefSeq identity
  • NM_021076
• Classification
  • Intermediate filaments Type IV
• VEGA ID
  OTTHUMG00000151155
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:4886
• Gene
  HFE
• Long gene name
  homeostatic iron regulator
• Synonyms gene name
  • hemochromatosis
• Synonyms
  • HLA-H
  • HFE1
• Synonyms name
  • high Fe
• Locus
  6p22.2
• Discovery year
  1986-01-01
• Entrez gene record
  3077
• Pubmed identfication
  • 3460331
  • 28474781
  • 9054933
• Classification
  • C1-set domain containing
• VEGA ID
  OTTHUMG00000016348
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
  • LRG_748

Gene info

• Identity
  HGNC:9761
• Gene
  RAB11B
• Long gene name
  RAB11B, member RAS oncogene family
• Synonyms
  • H-YPT3
• GenBank acession
  • X79780
• Locus
  19p13.2
• Discovery year
  1999-02-23
• Entrez gene record
  9230
• Pubmed identfication
  • 7811277
• RefSeq identity
  • NM_004218
• Classification
  • RAB, member RAS oncogene GTPases
• VEGA ID
  OTTHUMG00000182278

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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