C-C Motif Chemokine 2/CCL2/MCP-1
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Catalog numberE21-M78
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PricePlease ask
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Size10ug
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Shipping_TemperatureAmbient
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Product_StateLyophilized
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Formulation_DescriptionLyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
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StorageLyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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ReconstitutionAlways centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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PurityGreater than 95% as determined by reducing SDS-PAGE.
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EndotoxinLess than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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BackgroundThe chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
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Alternative NamesC-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2; CCL2
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Expression systemE.coli
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DescriptionChemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by EnoGene in 1.
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Gene target
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Gene symbolCCL2, SMC4, PFDN4, FOS, JUN, TAC4, MYB, PCK1, ROS1
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Short nameC-C Motif Chemokine 2/CCL2/MCP-1
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SpeciesHuman
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Alternative nameC-C Motif Chemokine 2/chemokine (C-C motif) ligand 2/MCP-1
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Alternative to gene targetchemokine (C-C motif) ligand 2, GDCF-2 and HC11 and HSMCR30 and MCAF and MCP-1 and MCP1 and SCYA2 and SMC-CF, CCL2 and IDBG-40504 and ENSG00000108691 and 6347, CCR2 chemokine receptor binding, Extracellular, Ccl2 and IDBG-204473 and ENSMUSG00000035385 and 20296, CCL2 and IDBG-630954 and ENSBTAG00000037811 and 281043
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Gene info
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Identity
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Gene
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Long gene nameC-C motif chemokine ligand 2
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Synonyms gene
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Synonyms gene name
- small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
- chemokine (C-C motif) ligand 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-07-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Chemokine ligands
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namestructural maintenance of chromosomes 4
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Synonyms gene
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Synonyms gene name
- SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
- SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-02-22
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Entrez gene record
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Pubmed identfication
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Classification
- Structural maintenance of chromosomes proteins
- Condensin I subunits
- Condensin II subunits
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprefoldin subunit 4
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Synonyms gene name
- prefoldin 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-08-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Prefoldin subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameFos proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-fos FBJ murine osteosarcoma viral oncogene homolog
- FBJ murine osteosarcoma viral oncogene homolog
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fos transcription factor family
- Basic leucine zipper proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameJun proto-oncogene, AP-1 transcription factor subunit
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Synonyms gene name
- v-jun avian sarcoma virus 17 oncogene homolog
- jun oncogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1988-05-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Basic leucine zipper proteins
- Jun transcription factor family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametachykinin precursor 4
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Synonyms gene name
- tachykinin 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-10-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tachykinin precursors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameMYB proto-oncogene, transcription factor
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Synonyms gene name
- v-myb avian myeloblastosis viral oncogene homolog
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Synonyms
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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Classification
- Myb/SANT domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namephosphoenolpyruvate carboxykinase 1
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Synonyms gene name
- phosphoenolpyruvate carboxykinase 1 (soluble)
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Synonyms
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Locus
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Discovery year1990-09-10
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameROS proto-oncogene 1, receptor tyrosine kinase
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Synonyms gene name
- v-ros avian UR2 sarcoma virus oncogene homolog 1
- v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
- c-ros oncogene 1 , receptor tyrosine kinase
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Receptor tyrosine kinases
- Fibronectin type III domain containing
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VEGA ID
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Locus Specific Databases