C-C Motif Chemokine 2/CCL2/MCP-1

  • Catalog number
    E21-M78
  • Price
    Please ask
  • Size
    10ug
  • Shipping_Temperature
    Ambient
  • Product_State
    Lyophilized
  • Formulation_Description
    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
  • Storage
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Purity
    Greater than 95% as determined by reducing SDS-PAGE.
  • Endotoxin
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
  • Background
    The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
  • Alternative Names
    C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2; CCL2
  • Expression system
    E.coli
  • Description
    Chemokines, chemokine receptors, ligands , motif chemokines and cytokines are supplied by EnoGene in 1.
  • Gene target
  • Gene symbol
    CCL2, SMC4, PFDN4, FOS, JUN, TAC4, MYB, PCK1, ROS1
  • Short name
    C-C Motif Chemokine 2/CCL2/MCP-1
  • Species
    Human
  • Alternative name
    C-C Motif Chemokine 2/chemokine (C-C motif) ligand 2/MCP-1
  • Alternative to gene target
    chemokine (C-C motif) ligand 2, GDCF-2 and HC11 and HSMCR30 and MCAF and MCP-1 and MCP1 and SCYA2 and SMC-CF, CCL2 and IDBG-40504 and ENSG00000108691 and 6347, CCR2 chemokine receptor binding, Extracellular, Ccl2 and IDBG-204473 and ENSMUSG00000035385 and 20296, CCL2 and IDBG-630954 and ENSBTAG00000037811 and 281043
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    structural maintenance of chromosomes 4
  • Synonyms gene
  • Synonyms gene name
    • SMC4 (structural maintenance of chromosomes 4, yeast)-like 1
    • SMC4 structural maintenance of chromosomes 4-like 1 (yeast)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-02-22
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Structural maintenance of chromosomes proteins
    • Condensin I subunits
    • Condensin II subunits
    • MicroRNA protein coding host genes
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
    FOS
  • Long gene name
    Fos proto-oncogene, AP-1 transcription factor subunit
  • Synonyms gene name
    • v-fos FBJ murine osteosarcoma viral oncogene homolog
    • FBJ murine osteosarcoma viral oncogene homolog
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Fos transcription factor family
    • Basic leucine zipper proteins
  • VEGA ID
Gene info
  • Identity
  • Gene
    JUN
  • Long gene name
    Jun proto-oncogene, AP-1 transcription factor subunit
  • Synonyms gene name
    • v-jun avian sarcoma virus 17 oncogene homolog
    • jun oncogene
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1988-05-11
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Basic leucine zipper proteins
    • Jun transcription factor family
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
    MYB
  • Long gene name
    MYB proto-oncogene, transcription factor
  • Synonyms gene name
    • v-myb avian myeloblastosis viral oncogene homolog
  • Synonyms
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Myb/SANT domain containing
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    ROS proto-oncogene 1, receptor tyrosine kinase
  • Synonyms gene name
    • v-ros avian UR2 sarcoma virus oncogene homolog 1
    • v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
    • c-ros oncogene 1 , receptor tyrosine kinase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1986-01-01
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Receptor tyrosine kinases
    • Fibronectin type III domain containing
  • VEGA ID
  • Locus Specific Databases
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