anti-PAK2 Antibody
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Catalog number3885
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoPAK2 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.
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Gene namesPAK2 Antibody: PAK65, PAKgammaGamma-PAK, PAK-2
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Antibodie s labelunlabelled serum
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PurityPAK2 Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenPAK2 antibody was made against a 14 amino acid synthetic peptide from near the carboxy terminus of human PAK2.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advicePAK2 antibody can be used for the detection of PAK2 by Western blot at 0.5 - 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
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Suspention pH azidePAK2 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atPAK2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman, Mouse, Rat
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Omim nr32483399
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Ncbi nrNP_002568
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Vial with antibodyin solution
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Quantity per ml1 mg/mL
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NCBI GENE nr5062
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GENE symbolPAK2
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Antigene namep21 protein (Cdc42/Rac)-activated kinase 2
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SourceHomo sapiens
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Protein nrQ13177
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolPAK2
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Short nameanti-PAK2 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toPAK2 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetp21 protein (Cdc42/Rac)-activated kinase 2, PAK65 and PAKgamma, PAK2 and IDBG-71333 and ENSG00000180370 and 5062, transferase activity, nuclei, Pak2 and IDBG-153570 and ENSMUSG00000022781 and 224105, PAK2 and IDBG-634020 and ENSBTAG00000047856 and 513673
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Gene info
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Identity
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Gene
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Long gene namep21 (RAC1) activated kinase 2
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Synonyms gene name
- p21 (CDKN1A)-activated kinase 2
- p21 protein (Cdc42/Rac)-activated kinase 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-03-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data