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hHR23b Antibody ALEXA FLUOR

hHR23b Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-15482R-A350 | hHR23b Antibody, ALEXA FLUOR 350 size: 100ul | 441.94 USD

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bs-15482R-A488 | hHR23b Antibody, ALEXA FLUOR 488 size: 100ul | 441.94 USD

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bs-15482R-A555 | hHR23b Antibody, ALEXA FLUOR 555 size: 100ul | 441.94 USD

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bs-15482R-A594 | hHR23b Antibody, ALEXA FLUOR 594 size: 100ul | 441.94 USD

Catalog number bs-15482R-A594
Price 441.94 USD
Size 100ul
Long name hHR23b Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
Also known as Anti-hHR23b PAb ALEXA FLUOR 594
Conjugated with ALEXA FLUOR® 594
Excitation emission 590nm/617nm
Properties For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
French translation anticorps
Label ALEXA FLUOR 594
Alternative name hHR23b Polyclonal Antibody, ALEXA FLUOR 594
1. Gene info
Identity 9813
Gene RAD23B
Long gene name RAD23 homolog B, nucleotide excision repair protein
Synonyms gene name
  • RAD23 (S. cerevisiae) homolog B
  • RAD23 homolog B (S. cerevisiae)
Synonyms
  • HHR23B
  • P58
  • HR23B
Synonyms name
  • XP-C repair complementing protein
  • XP-C repair complementing complex 58 kDa
Locus 9q31.2
Discovery year 1994-07-20
Entrez gene record 5887
Pubmed identfication
  • 7851894
  • 8168482
RefSeq identity
  • NM_002874
Classification
  • Nucleotide excision repair
Havana BLAST/BLAT OTTHUMG00000020446
Product images
    #.png#bs#.jpgFormalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-hHR23b Polyclonal Antibody, Unconjugated (bs-15482R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\\nLane 1: Raji lysates probed with Rabbit Anti-hHR23b Polyclonal Antibody, Unconjugated (bs-15482R) at 1:300 overnight at 4?C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37?C.
Product files

bs-15482R-A647 | hHR23b Antibody, ALEXA FLUOR 647 size: 100ul | 441.94 USD

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Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen hHR23b
Specificity This is a highly specific antibody against hHR23b.
Modification Unmodified
Modification Site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen range 10-60/409
Subcellular location Cytoplasm, Nucleus
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human hHR23b
Gene ID Number 5887
Swiss Prot P54727
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Crossreactivity Human, Mouse, Rat
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Purification Purified by Protein A.
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms P58; HR23B; HHR23B; UV excision repair protein RAD23 homolog B; XP-C repair-complementing complex 58 kDa protein; RAD23B
Gene targethHR23b
Short name Anti-hHR23b
Technique Antibody
Isotype Immunoglobulin G (IgG)
Alternative technique antibodies
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Anti-hHR23b | Technique alternative | 01011209107
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