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Human Recombinant HSP70 Protein

Human Recombinant HSP70 Protein is available 12 times from Stressmark proteins labs

SPR-103C | Human Recombinant HSP70 Protein size: 2x100 µg | 765.57 USD

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SPR-108A | Human Recombinant HSP70 Protein size: 50 µg | 332.96 USD

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SPR-117A | Human Recombinant HSP70 Protein size: 50 µg | 411.10 USD

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SPR-108C | Human Recombinant HSP70 Protein size: 2x100 µg | 765.57 USD

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SPR-115B | Human Recombinant HSP70 Protein size: 100 µg | 540.20 USD

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SPR-108B | Human Recombinant HSP70 Protein size: 100 µg | 436.01 USD

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SPR-115A | Human Recombinant HSP70 Protein size: 50 µg | 386.18 USD

Catalog number SPR-115A
Price 386.18 USD
Size 50 µg
Certificate of analysis This product has been certified >90% pure using SDS-PAGE analysis. The protein tested positive for ATPase activity using a Malachite Green assay.
Protein description Active Human Recombinant HSP70 Protein
Other name HSP70 1 Protein, HSP70 2 Protein, HSP70.1 Protein, HSP72 Protein, HSP73 Protein, HSPA1 Protein, HSPA1A Protein, HSPA1B Protein
NCBI number NM_005345
Relevant bio activity ATPase active
Protein expression model Baculovirus/Hi5 cells
Peptide sequence MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Protein purification Affinity Purified | Endotoxin-free
Recommended buffer for storage 20mM Tris, 150mM NaCl, 10% glycerol
Protein tag His tag
Bibliography 1. Zho J. (1998) Cell. 94: 471-480. 2. Boorstein, W. R., Ziegelhoffer, T. & Craig, E. A. (1993) J. Mol. Evol. 38(1): 1-17. 3. Rothman J. (1989) Cell. 59: 591 -601. 4. DeLuca-Flaherty et al. (1990) Cell. 62: 875-887. 5. Bork P., Sander C. & Valencia A. (1992) Proc. Natl Acad. Sci. USA. 89: 7290-7294. 6. Fink A.L. (1999) Physiol. Rev. 79: 425-449. 7. Smith D.F., et al., (1993) Mol. Cell. Biol. 13(2): 869-876. 8. Prapapanich V., et al., (1996) Mol. Cell. Biol. 16(11): 6200-6207. 9. Fernandez-Funez et al., (2000) Nature. 408(6808): 101-106.
Release date 1-Sep-2007
PubMed number 28026090, 22535471, 19953352
Tested applications Western Blot, Western Blot Control, Western Blot Control
Tested species reactivity Human
Representative figure legend SDS-Page of endotoxin-free his-tagged 70kDa human Hsp70 protein (SPR-115). SDS-Page of human HSP70 Protein (SPR-115)
Net weight (g) 0.05
1. Gene info
Identity 5233
Gene HSPA1B
Long gene name heat shock protein family A (Hsp70) member 1B
Synonyms gene name
  • heat shock 70kD protein 1B
  • heat shock 70kDa protein 1B
Synonyms
  • HSP70-2
Locus 6p21.33
Discovery year 1995-08-11
Entrez gene record 3304
Pubmed identfication
  • 1700760
Classification
  • TIM23 complex
  • Heat shock 70kDa proteins
Havana BLAST/BLAT OTTHUMG00000031202
2. Gene info
Identity 24989
Gene HSPBP1
Long gene name HSPA (Hsp70) binding protein 1
Synonyms gene name
  • HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Synonyms
  • FES1
Synonyms name
  • hsp70 interacting protein
Locus 19q13.42
Discovery year 2008-12-04
Entrez gene record 23640
Pubmed identfication
  • 10786638
  • 9830037
RefSeq identity
  • NM_012267
Classification
  • Armadillo like helical domain containing
Havana BLAST/BLAT OTTHUMG00000180705
Product images
    #Human#.jpg

SPR-117C | Human Recombinant HSP70 Protein size: 2x100 µg | 1,002.26 USD

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SPR-115C | Human Recombinant HSP70 Protein size: 2x100 µg | 934.31 USD

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SPR-117B | Human Recombinant HSP70 Protein size: 100 µg | 587.77 USD

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SPR-103B | Human Recombinant HSP70 Protein size: 100 µg | 436.01 USD

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SPR-103A | Human Recombinant HSP70 Protein size: 50 µg | 332.96 USD

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Stock availability In Stock
Scientific context HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacteria. The genes show a high degree of conservation, having at least 50% identity (2). The N-terminal two thirds of HSP70s are more conserved than the C-terminal third. HSP70 binds ATP with high affinity and possesses a weak ATPase activity which can be stimulated by binding to unfolded proteins and synthetic peptides (3). When HSC70 (constitutively expressed) present in mammalian cells was truncated, ATP binding activity was found to reside in an N-terminal fragment of 44kDa which lacked peptide binding capacity. Polypeptide binding ability therefore resided within the C-terminal half (4). The structure of this ATP binding domain displays multiple features of nucleotide binding proteins (5). All HSP70s, regardless of location, bind proteins, particularly unfolded ones. The molecular chaperones of the HSP70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding. The binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (6). The universal ability of HSP70s to undergo cycles of binding to and release from hydrophobic stretches of partially unfolded proteins determines their role in a great variety of vital intracellular functions such as protein synthesis, protein folding and oligomerization and protein transport. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at more.
Protein target HSP70
Protein reactivity Human
Primary research area Cancer, Heat Shock
Category Protein
Brand name none
Origin Recombinant
Gene number 3303
Protein number P08107
Verified applications WB, SDS-PAGE, ATPase Activity Assay, Functional Assay, ELISA
Purity pourcentage >90% High purity
Protein concentration Lot/batch specific. See included datasheet.
Protein specificity ~70 kDa
Storage recommendations -20°C
Shipping recommendations Blue Ice or 4°C
Supplementary useful information Please see included datasheet or contact us
Protein cell localization Cytoplasm
Warnings Non-hazardous materials
Protein origin Canada
Total weight (kg) 1.4
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Source Recombinants or rec. proteins
Group recombinants
Gene targetHSP70 Protein
Short name Recombinant HSP70 Protein
Technique Recombinant
Species Human
Alternative name H. sapiens recombinant HSP70 Protein
Alternative technique rec
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Recombinant HSP70 Protein | Technique alternative | 01012512
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