OTX015

• Catalog number
  2651-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  (6S)-​4-​(4-​chlorophenyl)-​N-​(4-​hydroxyphenyl)-​2,​3,​9-​trimethyl-​6H-​thieno[3,​2-​f][1,​2,​4]triazolo[4,​3-​a][1,​4]diazepine-​6-​acetamide; HY-15743
• Description
  OTX015 is a potent inhibitor of BRD2, BRD3, and BRD4 (EC₅₀s = 10-19 nM). It displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias, downregulating c-Myc expression and inducing cell cycle arrest and apoptosis. At 100 mg/kg, OTX015 has been shown to inhibit the growth of Ty82 BRD-NUT midline carcinoma tumors in nude mice by 79%.
• CAS Number
  202590-98-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₂ClN₅O₂S
• Molecular Weight
  492
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (~25 mg/ml) or EtOH (~ 25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A bromodomain family inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9936746
• PubChem CID Link
• SMILES
  CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C
• InChi
  nChI=1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
• InChi Key
  GNMUEVRJHCWKTO-FQEVSTJZSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  OTX015  
• Short name
  OTX015
• Alternative name
  OTX015

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