DOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS438470
• Price
  Please ask
• Size
  0.02 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [DOG-1 / TMEM16A / ANO1]
• Products_name_syn
  [Anoctamin 1, Calcium Activated Chloride Channel, Discovered On Gastrointestinal Stromal Tumors Protein 1,TAOS2, ORAOV2, TMEM16A]
• Other_names
  [anoctamin-1; Anoctamin-1; anoctamin-1; anoctamin 1; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2]
• Products_gene_name
  [TMEM16A]
• Other_gene_names
  [ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A]
• Clonality
  Monoclonal
• Clone
  [DG1/447 + DOG-1.1]
• Reactivity
  Human
• Specificity
  Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Canine or Canis Lupus is mostly Beagle used for drug research. MyBioSource produces ELISA test kits and polyclonal antibodies.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  TMEM16A   ANO1   Gastrointestinal   Stromal   Tumor   Monoclonal  
• Gene symbol
  ANO1, ANO1-AS1, LINC02584
• Short name
  -1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG
• Species
  Mouse, Dogs, Mouses
• Alternative name
  canine-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine
• Tissue
  tumor

Gene info

• Identity
  HGNC:21625
• Gene
  ANO1
• Long gene name
  anoctamin 1
• Synonyms gene
  • ORAOV2
  • TMEM16A
• Synonyms gene name
  • oral cancer overexpressed 2
  • transmembrane protein 16A
  • anoctamin 1, calcium activated chloride channel
• Synonyms
  • TAOS2
  • FLJ10261
  • DOG1
• GenBank acession
  • BC033036
• Locus
  11q13.3
• Discovery year
  2003-10-16
• Entrez gene record
  55107
• Pubmed identfication
  • 15067359
  • 18724360
  • 24692353
• RefSeq identity
  • NM_018043
• Classification
  • Anoctamins
• VEGA ID
  OTTHUMG00000167204

Gene info

• Identity
  HGNC:40016
• Gene
  ANO1-AS1
• Long gene name
  ANO1 antisense RNA 1
• Synonyms gene name
  • ANO1 antisense RNA 1 (non-protein coding)
• Locus
  11q13.3
• Discovery year
  2011-04-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000167205

Gene info

• Identity
  HGNC:33275
• Gene
  LINC02584
• Long gene name
  long intergenic non-protein coding RNA 2584
• Synonyms gene
  • C11orf78
  • NCRNA00224
  • ANO1-AS2
• Synonyms gene name
  • chromosome 11 open reading frame 78
  • non-protein coding RNA 224
  • ANO1 antisense RNA 2 (non-protein coding)
  • ANO1 antisense RNA 2
  • ANO1 antisense RNA 2 (head to head)
• GenBank acession
  • AW592641
  • EF419887
• Locus
  11q13.3
• Discovery year
  2007-01-29
• Entrez gene record
  100009613
• RefSeq identity
  • NR_103835
• Classification
  • Long intergenic non-protein coding RNAs
• VEGA ID
  OTTHUMG00000167162

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Similar products