MK-3102

Alternative_name

(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine; Omarigliptin
Description

MK-3102 is a potent, selective and long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor with IC₅₀ of 1.6 nM; highly selective over other proteases (QPP, DPP8, and FAP) tested.
CAS Number

1226781-44-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₇H₂₀F₂N₄O₃S
Molecular Weight

398.43
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent, selective and long-acting dipeptidyl peptidase-4 (DPP-4) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

46209133
PubChem CID Link
SMILES

CS(=O)(=O)N1C=C2CN(CC2=N1)C3CC(C(OC3)C4=C(C=CC(=C4)F)F)N
InChi

InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1
InChi Key

MKMPWKUAHLTIBJ-ISTRZQFTSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:7530
Gene

MVK
Long gene name

mevalonate kinase
Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
Synonyms
- LRBP
- MK
Synonyms name
- LH receptor mRNA-binding protein
- mevalonic aciduria
GenBank acession
- M88468
Locus

12q24.11
Discovery year

1992-10-06
Entrez gene record

4598
Pubmed identfication
- 1377680
RefSeq identity
- NM_000431
VEGA ID

OTTHUMG00000169256
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_156

Identity

HGNC:6888
Gene

MAPKAPK3
Long gene name

MAPK activated protein kinase 3
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
Synonyms
- 3pK
- MAPKAP3
- 3PK
- MK-3
- MK3
GenBank acession
- U43784
Locus

3p21.2
Discovery year

1999-03-26
Entrez gene record

7867
Pubmed identfication
- 8626550
- 8622688
RefSeq identity
- NM_004635
Classification
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000156850

Identity

HGNC:11529
Gene

EPCAM
Long gene name

epithelial cell adhesion molecule
Synonyms gene
- M4S1
- MIC18
- TACSTD1
Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
Synonyms
- Ly74
- TROP1
- GA733-2
- EGP34
- EGP40
- EGP-2
- KSA
- CD326
- Ep-CAM
- HEA125
- KS1/4
- MK-1
- MH99
- MOC31
- MOC-31
- 323/A3
- 17-1A
- TACST-1
- CO-17A
- ESA
- BerEp4
- Ber-Ep4
Synonyms name
- trophoblast cell surface antigen 1
GenBank acession
- M33011
Locus

2p21
Discovery year

1995-10-02
Entrez gene record

4072
Pubmed identfication
- 8382772
- 11306819
Classification
- MicroRNA protein coding host genes
- CD molecules
VEGA ID

OTTHUMG00000128853
Locus Specific Databases
- Global Variome shared LOVD
- LRG_215