AG490, JAK-2 kinase inhibitor

• Catalog number
  SIH-428-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  133550-30-8
• Description
  JAK-2 kinase inhibitor
• Molecular weight
  294,3 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  Tyrphostin AG 490, N-Benzyl-3,4-dihydroxybenzylidenecyanoacetamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C17H14N2O3
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (TLC)
• Soluble in
  Soluble in DMSO (30 mg/ml), dimethyl formamide (40 mg/ml) or 100% ethanol (10 mg/ml)
• Physical appearance
  Tan solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Acute toxicity, Oral (Category 3), H301 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H301 Toxic if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up.
• PubChem number
  5328779
• Scientific context
  AG490 is a selective inhibitor of JAK2/3 and EGF receptor tyrosine kinase. It also inhibits the downstream activation of STAT5a/b. AG490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
• Bibliography
  1. Abe M., et al. (2009) Int. Immunopharma. 9(7-8): 870–877. 2. De Vos J., Jourdan M., Tarte K., Jasmin C., & Klein B. (2000) British J. Haem. 109(4): 823–828. 3. Kirken R.A., et al. (1999) J. Leukocyte Biol. 65(6): 891–899.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of AG490 (SIH-428), a JAK-2 kinase inhibitor. CAS #: 133550-30-8. Molecular Formula: C17H14N2O3. Molecular Weight: 294.3 g/mol. Chemical structure of AG490, a JAK-2 kinase inhibitor (SIH-428). CAS # 133550-30-8. Molecular Formula: C17H14N2O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  AG490   JAK-2   kinase   inhibitor  
• Gene symbol
  JAK2, JAK3, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2
• Short name
  AG490, JAK-2 kinase inhibitor
• Alternative name
  AG490, JAK-2 phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:6192
• Gene
  JAK2
• Long gene name
  Janus kinase 2
• Synonyms
  • JTK10
• Locus
  9p24.1
• Discovery year
  1992-04-16
• Entrez gene record
  3717
• Pubmed identfication
  • 1848670
• Classification
  • FERM domain containing
  • Jak family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000019490
• Locus Specific Databases
  • LRG_612

Gene info

• Identity
  HGNC:6193
• Gene
  JAK3
• Long gene name
  Janus kinase 3
• Synonyms
  • L-JAK
  • JAKL
  • LJAK
  • JAK3_HUMAN
  • JAK-3
• Synonyms name
  • tyrosine-protein kinase JAK3
  • leukocyte Janus kinase
• GenBank acession
  • U31601
• Locus
  19p13.11
• Discovery year
  1994-12-19
• Entrez gene record
  3718
• Pubmed identfication
  • 8921370
  • 9226382
• RefSeq identity
  • NM_000215
• Classification
  • Jak family tyrosine kinases
• VEGA ID
  OTTHUMG00000165648
• Locus Specific Databases
  • JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency
  • LRG_77

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:34270
• Gene
  RNU6-2
• Long gene name
  RNA, U6 small nuclear 2
• Synonyms
  • U6-2
• Locus
  19p13.3
• Discovery year
  2008-06-10
• Entrez gene record
  103625684
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_125730
• Classification
  • Small nuclear RNAs

Gene info

• Identity
  HGNC:18923
• Gene
  KRTAP13-2
• Long gene name
  keratin associated protein 13-2
• Synonyms
  • KAP13-2
• GenBank acession
  • AP001708
• Locus
  21q22.11
• Discovery year
  2003-02-21
• Entrez gene record
  337959
• Pubmed identfication
  • 12359730
• Classification
  • Keratin associated proteins
• VEGA ID
  OTTHUMG00000057793

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