6-Formylindolo(3,2-b)carbazole, Ah receptor ligand

• Catalog number
  SIH-383-500UG
• Price
  Please ask
• Size
  500 µg

• Stock availabilitIn Stock
  In Stock
• CAS number
  172922-91-7
• Description
  Ah receptor ligand
• Molecular weight
  284,3 g/mol
• Primary research fields
  Cell Signaling
• Other name
  Indolo[3,2-b]carbazole-6-carbaldehyde, FICZ
• Product category
  Small Molecules
• Product type
  Ligand
• Chemical formula
  C19H12N2O
• Origin
  Synthetic
• Purity pourcentage
  >95%
• Soluble in
  Soluble in DMSO (10 mg/ml)
• Physical appearance
  Yellow solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Caution. Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25 - Avoid contact with skin and eyes
• PubChem number
  22245026
• Scientific context
  A tryptophan-derived, high affinity aryl hydrocarbon receptor ligand (Kd=7x10-11 M). Proposed to be an endogenous AhR ligand. Induces rapid and transient expression of cytochrome P450-1A1 (CYP1A1) in human cells at 100 pM.
• Bibliography
  1. Wei Y.D., et al. (1998) Chem. Biol. Interact. 110(1-2): 39-55. 2. Rannug U., et al. (1995) Chem. Biol. Drug. Des. 2(12): 841-855. 3. Rannug A., et al. (1987) J. Biol. Chem. 262(32): 15422-7.
• Release date
  17-Jul-2013
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of 6-Formylindolo(3,2-b)carbazole (SIH-383), a Ah receptor ligand. CAS #: 172922-91-7. Molecular Formula: C19H12N2O. Molecular Weight: 284.3 g/mol. Chemical structure of 6-Formylindolo(3,2-b)carbazole, a Ah receptor ligand (SIH-383). CAS # 172922-91-7. Molecular Formula: C19H12N2O.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.0005
• Other related products
• Additional description
  FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  6-Formylindolo   2-b   carbazole   receptor   ligand  
• Short name
  6-Formylindolo(3 2-b)carbazole, Ah receptor ligand
• Alternative name
  6-Formylindolo(3,2-b)carbazole, Ah receptor ligand

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