CFTR Inhibitor-172

• Catalog number
  2487-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoic acid; CFTR(inh)-172
• Description
  A potent, reversible, selective, CFTR chloride channel blocker. Inhibits CFTR short-circuit current in < 2 minutes in a voltage-independent manner (Ki = ~ 300 nM). At concentrations fully inhibiting CFTR, CFTR(inh)-172 does not block increase of cellular cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(⁺) channels, or a series of other transporters.
• CAS Number
  307510-92-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₀F₃NO₃S₂
• Molecular Weight
  409.4
• Cell Permeable
  No
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>10 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  Apotent, CFTR chloride channel blocker
• Storage Condition
  - 20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD06411408
• PubChem CID
  1554208
• PubChem CID Link
• SMILES
  C1=CC(=CC(=C1)N2C(=O)C(=CC3=CC=C(C=C3)C(=O)O)SC2=S)C(F)(F)F
• InChi
  InChI=1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8-
• InChi Key
  JIMHYXZZCWVCMI-ZSOIEALJSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  CFTR   Inhibitor-172  
• Gene symbol
  CFTR, CFTR-AS1
• Short name
  CFTR Inhibitor-172
• Alternative name
  cystic fibrosis transmembrane conductance regulator (adenosine triphosphate-binding cassette sub-family C, member 7) suppressor-172
• Alternative to gene target
  cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7), ABC35 and ABCC7 and CF and CFTR/MRP and dJ760C5.1 and MRP7 and TNR-CFTR, CFTR and IDBG-37713 and ENSG00000001626 and 1080, ATPase activity, Cell surfaces, Cftr and IDBG-129229 and ENSMUSG00000041301 and 12638, CFTR and IDBG-632747 and ENSBTAG00000006589 and 281067

Gene info

• Identity
  HGNC:1884
• Gene
  CFTR
• Long gene name
  CF transmembrane conductance regulator
• Synonyms gene
  • CF
  • ABCC7
• Synonyms gene name
  • cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
• Synonyms
  • MRP7
  • ABC35
  • TNR-CFTR
  • dJ760C5.1
  • CFTR/MRP
• Synonyms name
  • ATP-binding cassette sub-family C, member 7
• GenBank acession
  • M28668
• Locus
  7q31.2
• Discovery year
  1986-01-01
• Entrez gene record
  1080
• Pubmed identfication
  • 2772657
• RefSeq identity
  • NM_000492
• Classification
  • ATP binding cassette subfamily C
  • Chloride channels, ATP-gated CFTR
• VEGA ID
  OTTHUMG00000023076
• Locus Specific Databases
  • Cystic Fibrosis
  • LRG_663

Gene info

• Identity
  HGNC:40144
• Gene
  CFTR-AS1
• Long gene name
  CFTR antisense RNA 1
• Synonyms
  • BGas
• GenBank acession
  • BG213071
• Locus
  7q31.2
• Discovery year
  2017-07-26
• Entrez gene record
  111082987
• Pubmed identfication
  • 27434588
• RefSeq identity
  • NR_149084
• Classification
  • Antisense RNAs

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