Anti-CD46/MCP (Polyclonal), ALEXA Fluor 594

  • Catalog number
    GENTObs-1529R-A594
  • Price
    Please ask
  • Size
    100 microliters
  • Type
    Conjugated Primary Antibody
  • Conjugated with
    ALEXA FLUOR® 594
  • Host organism
    Rabbit (Oryctolagus cuniculus)
  • Target Protein Peptide
    CD46/MCP
  • Specificity
    This antibody reacts specifically with CD46/MCP
  • Modification
    No modification has been applied to this antibody
  • Modification site
    None
  • Clonality
    Polyclonal Antibody
  • Clone
    Polyclonal Antibodies
  • Concentration
    1ug per 1ul
  • Subcellular locations
    Cytoplasm
  • Antigen Source
    KLH conjugated synthetic peptide derived from Mouse CD46
  • Gene ID
    4179
  • Swiss Prot
    P15529
  • Applications
    IF(IHC-P)
  • Applications with corresponding dilutions
    IF(IHC-P)(1:50-200)
  • Cross reactive species
    Mouse (Mus musculus)
  • Cross Reactive Species details
    No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
  • Purification method
    Purified by Protein A.
  • Storage
    Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Excitation emission
    590nm/617nm
  • Synonyms
    MCP; TLX; AHUS2; MIC10; TRA2.10; Membrane cofactor protein; Trophoblast leukocyte common antigen; CD46
  • Also known as
    CD46/MCP Polyclonal Antibody
  • Other name
    Anti-CD46/MCP Polyclonal
  • Advisory
    Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Properties
    For facs or microscopy Alexa 1 conjugate.
  • Conjugation
    Alexa Fluor, ALEXA FLUOR® 594
  • Conjugated
    Alexa conjugate 1
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Group
    Polyclonals and antibodies
  • About
    Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
  • Gene target
  • Gene symbol
    CD46, CAPG, CCL8, SLC25A33, CCL7, CCL13, CCR2, CCL2
  • Short name
    Anti-CD46/MCP
  • Technique
    Polyclonal, anti-, anti, antibody to, antibodies, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
  • Isotype
    Immunoglobulin G (IgG)
  • Label
    ALEXA FLUOR 594
  • Alternative name
    CD46/MCP Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
  • Alternative technique
    polyclonals, antibodies
  • Alternative to gene target
    CD46 molecule, complement regulatory protein, AHUS2 and MCP and MIC10 and TLX and TRA2.10, CD46 and IDBG-106372 and ENSG00000117335 and 4179, cadherin binding, Cell surfaces, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, BT.68611 and IDBG-638462 and ENSBTAG00000005397 and 280851
Gene info
  • Identity
  • Gene
  • Long gene name
    CD46 molecule
  • Synonyms gene
  • Synonyms gene name
    • antigen identified by monoclonal antibody TRA-2-10
    • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
    • CD46 antigen, complement regulatory protein
    • CD46 molecule, complement regulatory protein
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1988-08-31
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Sushi domain containing
    • Complement system regulators and receptors
    • CD molecules
  • VEGA ID
  • Locus Specific Databases
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    C-C motif chemokine ligand 8
  • Synonyms gene
  • Synonyms gene name
    • small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
    • chemokine (C-C motif) ligand 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-11-14
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Chemokine ligands
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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