Ro 31-8220 methanesulfonate
-
Catalog number1946-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_name2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX
-
DescriptionCell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).
-
CAS Number138489-18-6
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₂₅H₂₃N₅O₂S.CH₄O₃S
-
Molecular Weight553.65
-
Cell PermeableYes
-
Purity≥98% by NMR
-
SolubilitiesDMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
-
HandlingProtect from light and air
-
Tag LineA potent PKC inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
MDL NumberMFCD03788207
-
PubChem CID11628205
-
SMILESCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
-
InChiInChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
-
InChi KeySAWVGDJBSPLRRB-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Gene target
-
Gene symbolSNORD114-31, SNORD115-31, ERVK-31, IGKV3-31, IGLV3-31, RNVU1-31, IGKV3D-31, IL31, OR1D5, RNU6-31P
-
Short nameRo 31-8220 methanesulfonate
-
Alternative nameRo 31-8220 methanesulfonate
-
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-31
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 115-31
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2007-02-15
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameendogenous retrovirus group K member 31
-
Synonyms gene name
- endogenous retrovirus group K, member 31
-
GenBank acession
-
Locus
-
Discovery year2015-05-14
-
Pubmed identfication
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin kappa variable 3-31 (pseudogene)
-
Synonyms gene name
- immunoglobulin kappa variable 3-31
- immunoglobulin kappa variable 3-31 pseudogene
-
GenBank acession
-
Locus
-
Discovery year2000-04-18
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin kappa locus at 2p11.2
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin lambda variable 3-31 (pseudogene)
-
Synonyms gene name
- immunoglobulin lambda variable 3-31
- immunoglobulin lambda variable 3-31 pseudogene
-
GenBank acession
-
Locus
-
Discovery year2000-05-08
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin lambda locus at 22q11.2
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameRNA, variant U1 small nuclear 31
-
Locus
-
Discovery year2019-07-25
-
Classification
- Variant U1 small nuclear RNAs
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin kappa variable 3D-31 (pseudogene)
-
Synonyms gene name
- immunoglobulin kappa variable 3D-31
- immunoglobulin kappa variable 3D-31 pseudogene
-
GenBank acession
-
Locus
-
Discovery year2000-04-18
-
Entrez gene record
-
RefSeq identity
-
Classification
- Immunoglobulin kappa locus at 2p11.2
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameinterleukin 31
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-11-06
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Interleukins
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameolfactory receptor family 1 subfamily D member 5
-
Synonyms gene name
- olfactory receptor, family 1, subfamily D, member 5
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year1998-09-14
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Olfactory receptors, family 1
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameRNA, U6 small nuclear 31, pseudogene
-
Synonyms gene
-
Synonyms gene name
- RNA, U6 small nuclear 31
-
Locus
-
Discovery year2008-06-10
-
Entrez gene record
-
RefSeq identity