Ro 31-8220 methanesulfonate

  • Catalog number
    1946-5
  • Price
    Please ask
  • Size
    5 mg
  • Alternative_name
    2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX
  • Description
    Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).
  • CAS Number
    138489-18-6
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₅H₂₃N₅O₂S.CH₄O₃S
  • Molecular Weight
    553.65
  • Cell Permeable
    Yes
  • Purity
    ≥98% by NMR
  • Solubilities
    DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
  • Handling
    Protect from light and air
  • Tag Line
    A potent PKC inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD03788207
  • PubChem CID
    11628205
  • SMILES
    CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
  • InChi
    InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
  • InChi Key
    SAWVGDJBSPLRRB-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
  • Gene symbol
    SNORD114-31, SNORD115-31, ERVK-31, IGKV3-31, IGLV3-31, RNVU1-31, IGKV3D-31, IL31, OR1D5, RNU6-31P
  • Short name
    Ro 31-8220 methanesulfonate
  • Alternative name
    Ro 31-8220 methanesulfonate
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    endogenous retrovirus group K member 31
  • Synonyms gene name
    • endogenous retrovirus group K, member 31
  • GenBank acession
  • Locus
  • Discovery year
    2015-05-14
  • Pubmed identfication
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin kappa variable 3-31 (pseudogene)
  • Synonyms gene name
    • immunoglobulin kappa variable 3-31
    • immunoglobulin kappa variable 3-31 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-18
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin kappa locus at 2p11.2
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin lambda variable 3-31 (pseudogene)
  • Synonyms gene name
    • immunoglobulin lambda variable 3-31
    • immunoglobulin lambda variable 3-31 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-05-08
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin lambda locus at 22q11.2
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    RNA, variant U1 small nuclear 31
  • Locus
  • Discovery year
    2019-07-25
  • Classification
    • Variant U1 small nuclear RNAs
Gene info
  • Identity
  • Gene
  • Long gene name
    immunoglobulin kappa variable 3D-31 (pseudogene)
  • Synonyms gene name
    • immunoglobulin kappa variable 3D-31
    • immunoglobulin kappa variable 3D-31 pseudogene
  • GenBank acession
  • Locus
  • Discovery year
    2000-04-18
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Immunoglobulin kappa locus at 2p11.2
  • VEGA ID
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    olfactory receptor family 1 subfamily D member 5
  • Synonyms gene name
    • olfactory receptor, family 1, subfamily D, member 5
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1998-09-14
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Olfactory receptors, family 1
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    RNA, U6 small nuclear 31, pseudogene
  • Synonyms gene
  • Synonyms gene name
    • RNA, U6 small nuclear 31
  • Locus
  • Discovery year
    2008-06-10
  • Entrez gene record
  • RefSeq identity
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