Recombinant Rat IL4R / Il4ra Protein (His tag)
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Catalog number
PKSR030322-50µg
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Price
Please ask
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Size
50µg
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Synonym
IL4R;Il4ra
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Activity
Measured by its ability to bind biotinylated mouse IL4-His in a functional ELISA.
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Sequence
Met1-Arg232
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Fusion tag
C-His
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Accession
Q63257-1
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ExpressedHost
HEK293 Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
> 95 % as determined by SDS-PAGE
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Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
25.3 kDa
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AP Mol Mass
25.3 kDa
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Formulation
Lyophilized from sterile PBS, pH 7.4
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Background
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD124, also known as interleukin 4 receptor (IL4R), is a typeⅠ transmembrane protein that can regulate IgE antibody production in B cells through binding to interleukin 4 and interleukin 13 and promote differentiation of Th2 cells through binding to interleukin 4. The membrane-bound form of CD124 can be hydrolyzed to soluble form which can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells.
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Conjugation
histidine
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin name
Rattus norvegicus
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IL4R
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Short name
Recombinant IL4R / Il4ra Protein (His tag)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Host
Rat
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Label
His
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Species
Rat, Rats
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Alternative name
Rec. Rat interleukin 4 receptor / Il4ra Protein (histidine detection labelled)
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Alternative technique
rec
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Alternative to gene target
interleukin 4 receptor, CD124 and IL-4RA and IL4RA, IL4R and IDBG-21808 and ENSG00000077238 and 3566, insulin receptor substrate binding, Extracellular, Il4ra and IDBG-209275 and ENSMUSG00000030748 and 16190, IL4R and IDBG-638778 and ENSBTAG00000001602 and 404154
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Gene info
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Identity
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Gene
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Long gene name
interleukin 4 receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1990-07-06
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Entrez gene record
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Pubmed identfication
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Classification
- Interleukin receptors
- CD molecules
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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