Recombinant Human Peroxiredoxin-1/PRDX1 Protein(N, C-6His)

• Catalog number
  PKSH032881-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  Peroxiredoxin-1;Natural killer cell-enhancing factor A;NKEF-A;Proliferation-associated gene protein;PAG;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2;PAGA; PAGB; TDPX2
• Activity
  NA
• Sequence
  Met1-Lys199
• Fusion tag
  N,C-6His
• Accession
  Q06830
• Expressed Host
  E.coli
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
• Mol Mass
  25.3 kDa
• AP Mol Mass
  26 kDa
• Formulation
  Supplied as a 0.2 μm filtered solution of PBS, 10% glycerol, 0.1mM DTT,pH 6.0.
• Background
  Peroxiredoxin-1(PRDX1) contains 1 thioredoxin domain and belongs to the AhpC/TSA family. PRDX1 constitutively expressed in most human cells and it is induced to higher levels upon serum stimulation in untransformed and transformed cells. PRDX1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and play an important role in eliminating peroxides generated during metabolism. PRDX1 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. It reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. It may contribute to the antiviral activity of CD8(+) T-cells and have a proliferative effect in cancer development or progression.
• Technical data
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Peroxiredoxin-1/PRDX1   Protein   C-6His  
• Gene symbol
  PRDX1
• Short name
  Recombinant Peroxiredoxin-1/PRDX1 Protein(N, C-6His)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Peroxiredoxin-1/peroxiredoxin 1 Protein(N, C-6His)
• Alternative technique
  rec
• Alternative to gene target
  peroxiredoxin 1, MSP23 and NKEF-A and NKEFA and PAG and PAGA and PAGB and PRX1 and PRXI and TDPX2, PRDX1 and IDBG-97953 and ENSG00000117450 and 5052, peroxiredoxin activity, nuclei, Prdx1 and IDBG-178542 and ENSMUSG00000028691 and 18477, PRDX1 and IDBG-640075 and ENSBTAG00000003642 and 281997

Gene info

• Identity
  HGNC:9352
• Gene
  PRDX1
• Long gene name
  peroxiredoxin 1
• Synonyms gene
  • PAGA
• Synonyms
  • NKEFA
• GenBank acession
  • BC021683
• Locus
  1p34.1
• Discovery year
  1993-11-01
• Entrez gene record
  5052
• Pubmed identfication
  • 8496166
• RefSeq identity
  • NM_181697
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000007738

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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