Recombinant Human Peroxiredoxin 1 / PRDX1 Protein (His tag)

• Catalog number
  PKSH031213-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  MSP23;NKEF-A;NKEFA;PAG;PAGA;PAGB;PRX1;PRXI;TDPX2
• Activity
  NA
• Sequence
  Met 1-Lys 199
• Fusion tag
  C-His
• Accession
  NP_002565.1
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞97 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  22.9 kDa
• AP Mol Mass
  22.9 kDa
• Formulation
  Lyophilized from sterile PBS, 10% glycerol, 0.1mM DTT, pH 7.5
• Background
  Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Peroxiredoxin   PRDX1   Protein   His   tag  
• Gene symbol
  PRDX1
• Short name
  Recombinant Peroxiredoxin 1 / PRDX1 Protein (His tag)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Peroxiredoxin 1 / peroxiredoxin 1 Protein (histidine detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  peroxiredoxin 1, MSP23 and NKEF-A and NKEFA and PAG and PAGA and PAGB and PRX1 and PRXI and TDPX2, PRDX1 and IDBG-97953 and ENSG00000117450 and 5052, peroxiredoxin activity, nuclei, Prdx1 and IDBG-178542 and ENSMUSG00000028691 and 18477, PRDX1 and IDBG-640075 and ENSBTAG00000003642 and 281997

Gene info

• Identity
  HGNC:9352
• Gene
  PRDX1
• Long gene name
  peroxiredoxin 1
• Synonyms gene
  • PAGA
• Synonyms
  • NKEFA
• GenBank acession
  • BC021683
• Locus
  1p34.1
• Discovery year
  1993-11-01
• Entrez gene record
  5052
• Pubmed identfication
  • 8496166
• RefSeq identity
  • NM_181697
• Classification
  • Peroxiredoxins
• VEGA ID
  OTTHUMG00000007738

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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