Active Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A)

• Catalog number
  APA813Hu01
• Price
  Please ask
• Size
  1mg

• Source
  NA
• Predicted Molecular Mass KD
  40.8kDa
• Accurate Molecular Mass KD
  44kDa
• Organism species
  Homo sapiens (Human)
• Item Name
  Tumor Necrosis Factor Receptor Superfamily, Member 12A
• Alternative Names
  CD266; TNFRSF12-A; FN14; TWEAKR; Tumour Necrosis Factor Related Weak Inducer Of Apoptosis; Fibroblast growth factor-inducible immediate-early response protein 14
• Research Area
  CD & Adhesion molecule;Tumor immunity;
• Buffer Formulation
  20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Traits
  Freeze-dried powder
• Isoelectric Point
  6.7
• Purity
  > 80%
• Protein length
  Ser24~Ala126
• Tag
  N-terminal His and GST Tag
• Expression System
  NA
• Application
  Cell culture; Activity Assays.
• Manual link
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Active   Tumor   Necrosis   Factor   Receptor   Superfamily   Member   12A   TNFRSF12A  
• Gene symbol
  TNFRSF12A, IL12A
• Short name
  Active Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A)
• Host
  E. coli
• Species
  Homo sapiens (Human)
• Alternative name
  functionnal Tumor Necrosis Factor Receptor supergroup, Member 12A (tumor necrosis factor receptor superfamily, member 12A)
• Alternative to gene target
  tumor necrosis factor receptor superfamily, member 12A, TNFRSF12A and IDBG-11328 and ENSG00000006327 and 51330, protein binding, Cell surfaces, Tnfrsf12a and IDBG-143687 and ENSMUSG00000023905 and 27279, BT.20111 and IDBG-635818 and ENSBTAG00000012082 and 617439
• Tissue
  tumor

Gene info

• Identity
  HGNC:18152
• Gene
  TNFRSF12A
• Long gene name
  TNF receptor superfamily member 12A
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 12A
• Synonyms
  • FN14
  • TweakR
  • CD266
• GenBank acession
  • AB035480
• Locus
  16p13.3
• Discovery year
  2002-12-20
• Pubmed identfication
  • 10751351
  • 10551889
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000129001

Gene info

• Identity
  HGNC:5969
• Gene
  IL12A
• Long gene name
  interleukin 12A
• Synonyms gene
  • NKSF1
• Synonyms gene name
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
• Synonyms
  • CLMF
  • IL-12A
  • p35
  • NFSK
• Synonyms name
  • natural killer cell stimulatory factor 1, 35 kD subunit
  • cytotoxic lymphocyte maturation factor 1, p35
  • interleukin 12, p35
  • IL-12, subunit p35
  • NF cell stimulatory factor chain 1
  • interleukin-12 alpha chain
  • IL35 subunit
• GenBank acession
  • M65271
• Locus
  3q25.33
• Discovery year
  1991-08-08
• Entrez gene record
  3592
• Pubmed identfication
  • 1673147
• RefSeq identity
  • NM_000882
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000158942

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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