Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker) Mouse Monoclonal Antibody

• Catalog number
  MBS439717
• Price
  Please ask
• Size
  0.02 mg (With BSA & Azide at 0.2mg/mL)

• Products_type
  Antibody
• Products_short_name
  [Wilm's Tumor 1 (WT1)]
• Products_name_syn
  [WT1; AWT1; FWT1; GUD; NPHS4; WAGR; Wilms tumor 1]
• Other_names
  [Wilms tumor protein isoform A; Wilms tumor protein; Wilms tumor protein; Wilms tumor 1; WT33]
• Products_gene_name
  [WT1]
• Other_gene_names
  [WT1; WT1; GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1]
• Clonality
  Monoclonal
• Clone
  [WT1/857 + 6F-H2]
• Reactivity
  Human and Rat. Others-not known
• Specificity
  Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm’s tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm’s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the mesotheliomas.
• Form
  200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Storage_stability
  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Tested_application
  mmunohistology (Formalin-fixed)
• Properties
  If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• French translation
  anticorps

• Gene target
  Wilm's   Tumor   WT1   Wilm's   Tumor   Mesothelial   Monoclonal  
• Gene symbol
  WT1-AS, WT1
• Short name
  Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial ) Mouse Monoclonal Antibody
• Technique
  Mouse monoclonal, Antibody, Mouse, antibodies against human proteins, antibodies for, Component cell markers and DNA bp. markers are genetic markers er genes or DNA sequences with a known location on a chromosome that can be used to identify individuals or species. Protein markers in kDA. Monoclonals or monoclonal antibodies, mouses, mouse monoclonals
• Host
  Mouse, Murine monoclonal antibodies or Mabs are often conjugated and the isotype is IgG.
• Isotype
  IgG1, kappa
• Species
  Mouse, Mouses
• Alternative name
  Wilm's Tumor 1 (Wilms tumor 1) (Wilm's Tumor & Mesothelial detection labelled) Mouse monoclonal (antibody to-)
• Alternative technique
  antibodies, murine
• Alternative to gene target
  Wilms tumor 1, AWT1 and EWS-WT1 and GUD and NPHS4 and WAGR and WIT-2 and WT33, WT1 and IDBG-37982 and ENSG00000184937 and 7490, C2H2 zinc finger domain binding, nuclei, Wt1 and IDBG-194872 and ENSMUSG00000016458 and 22431, WT1 and IDBG-636230 and ENSBTAG00000047268 and 782183
• Tissue
  tumor

Gene info

• Identity
  HGNC:18135
• Gene
  WT1-AS
• Long gene name
  WT1 antisense RNA
• Synonyms gene
  • WIT1
• Synonyms gene name
  • Wilms tumor upstream neighbor 1
  • WT1 antisense RNA (non-protein coding)
• Synonyms
  • WIT-1
  • WT1AS
  • WT1-AS1
• Synonyms name
  • Wilms tumor associated protein
• GenBank acession
  • BC002734
• Locus
  11p13
• Discovery year
  2005-10-28
• Entrez gene record
  51352
• Pubmed identfication
  • 2173145
  • 8406502
  • 17210670
• RefSeq identity
  • NR_023920
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000039557

Gene info

• Identity
  HGNC:12796
• Gene
  WT1
• Long gene name
  WT1 transcription factor
• Synonyms gene
  • GUD
• Synonyms gene name
  • Wilms tumor 1
• Synonyms
  • WAGR
  • WIT-2
  • AWT1
  • NPHS4
  • WT-1
• Locus
  11p13
• Discovery year
  1989-04-13
• Entrez gene record
  7490
• Pubmed identfication
  • 14681303
  • 9810227
• RefSeq identity
  • NM_000378
• Classification
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000039556
• Locus Specific Databases
  • LRG_525

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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