TP-3654

Alternative_name

2-((1R,4R)-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
Description

TP-3654 is a second-generation Pim kinase inhibitor with Ki values of 5 and 42 nM for Pim-1 and Pim-3, respectively. Displays anticancer activities.
CAS Number

1361951-15-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H2₂₅F₃N₄O
Molecular Weight

418.46
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent second-generation Pim kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

66598080
PubChem CID Link
SMILES

CC(C)(C1CCC(CC1)NC2=NN3C(=NC=C3C4=CC(=CC=C4)C(F)(F)F)C=C2)O
InChi

InChI=1S/C22H25F3N4O/c1-21(2,30)15-6-8-17(9-7-15)27-19-10-11-20-26-13-18(29(20)28-19)14-4-3-5-16(12-14)22(23,24)25/h3-5,10-13,15,17,30H,6-9H2,1-2H3,(H,27,28)
InChi Key

XRNVABDYQLHODA-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:6525
Gene

LCN1
Long gene name

lipocalin 1
Synonyms gene name
- lipocalin 1 (protein migrating faster than albumin, tear prealbumin)
- lipocalin 1 (tear prealbumin)
Synonyms
- VEGP
- TP
- PMFA
- MGC71975
- TLC
Synonyms name
Locus

9q34.3
Discovery year

1993-05-03
Entrez gene record

3933
Pubmed identfication
- 8276406
RefSeq identity
- NM_002297
Classification
- Lipocalins
VEGA ID

OTTHUMG00000020908