A selective agonist for PPARδ (peroxisome proliferator-activated receptorδ) (EC₅₀ = 1. 1 nM), displaying 1000-fold selectivity over the other human subtypes. In macrophages, fibroblasts, and intestinal cells, GW501516 increases expression of the reverse cholesterol transporter ATP-binding cassette A1 and induces apolipoprotein A1-specific cholesterol efflux.
Is it cell-permeable?
≥98% by HPLC
Is this a salt?
Protect from light and air
Maximum time for storage
White to off-white solid
DMSO (50 mg/ml) or EtOH (12 mg/ml)
For cells, cell lines and tissues in culture till half confluency.