(S)-H-1152 dihydrochloride

Alternative_name

(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Description

H-1152 dihydrochloride is a potent, cell permeable, specific, ATP-competitive inhibitor of Rho-kinase (ROCK) (Ki = 1.6 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).
CAS Number

451462-58-1
Structure Available

Yes
Salt Form

Yes
Molecular Formula

C₁₆H₂₁N₃O₂S.2HCl
Molecular Weight

392.34
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>15 mg/ml)
Handling

Protect from air and moisture
Tag Line

A potent, specific ATP-competitive rho-kinase (ROCK) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD06411451
PubChem CID

11560225
PubChem CID Link
SMILES

CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl
InChi

InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
InChi Key

BFOPDSJOLUQULZ-GXKRWWSZSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

H-1152 dihydrochloride
Gene symbol

NCAPH, HLA-H, IGHV3-69-1, FUT1, PIGH, NEFH, HFE, RAB11B, ATCAY, RAB35
Short name

(S)-H-1152 dihydrochloride
Alternative name

(S)-H-1152 dihydrochloride

Identity

HGNC:1112
Gene

NCAPH
Long gene name

non-SMC condensin I complex subunit H
Synonyms gene
- BRRN1
Synonyms gene name
- barren (Drosophila) homolog
- barren homolog (Drosophila)
- barren homolog 1 (Drosophila)
- non-SMC condensin I complex, subunit H
Synonyms
- CAP-H
- hCAP-H
GenBank acession
- BC024211
Locus

2q11.2
Discovery year

1998-02-11
Entrez gene record

23397
Pubmed identfication
- 9417923
RefSeq identity
- NM_015341
Classification
- Condensin I subunits
- Kleisins
VEGA ID

OTTHUMG00000130451

Identity

HGNC:5631
Gene

IGHV3-69-1
Long gene name

immunoglobulin heavy variable 3-69-1 (pseudogene)
Synonyms gene
- IGHV3-H
Synonyms gene name
- immunoglobulin heavy variable 3-H (provisional)
- immunoglobulin heavy variable 3-H pseudogene (provisional)
- immunoglobulin heavy variable 3-H (pseudogene)
Synonyms
- IGHV3-h
GenBank acession
- AJ879484
Locus

14q32.33
Discovery year

2000-04-04
Entrez gene record

28402
Pubmed identfication
- 16133446
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000191145

Identity

HGNC:4012
Gene

FUT1
Long gene name

fucosyltransferase 1 (H blood group)
Synonyms gene
- H
- HSC
Synonyms gene name
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included)
- fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
Synonyms name
- galactoside 2-alpha-L-fucosyltransferase
Locus

19q13.33
Discovery year

1989-06-06
Entrez gene record

2523
RefSeq identity
- NM_000148
Classification
- Fucosyltransferases
- Blood group antigens
VEGA ID

OTTHUMG00000183325
Locus Specific Databases
- Blood Group Antigen Mutation Database
- LRG_810

Identity

HGNC:7737
Gene

NEFH
Long gene name

neurofilament heavy chain
Synonyms gene name
- neurofilament, heavy polypeptide 200kDa
- neurofilament heavy polypeptide
- neurofilament heavy
Synonyms
- NF-H
- NFH
Locus

22q12.2
Discovery year

1988-08-31
Entrez gene record

4744
RefSeq identity
- NM_021076
Classification
- Intermediate filaments Type IV
VEGA ID

OTTHUMG00000151155
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Identity

HGNC:4886
Gene

HFE
Long gene name

homeostatic iron regulator
Synonyms gene name
- hemochromatosis
Synonyms
- HLA-H
- HFE1
Synonyms name
- high Fe
Locus

6p22.2
Discovery year

1986-01-01
Entrez gene record

3077
Pubmed identfication
- 3460331
- 28474781
- 9054933
Classification
- C1-set domain containing
VEGA ID

OTTHUMG00000016348
Locus Specific Databases
- ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database
- LRG_748