Pelitinib (EKB-569)

Alternative_name

(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
Description

Pelitinib is a pan-ErbB tyrosine kinase inhibitor with potential anticancer activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors.
CAS Number

257933-82-7
Structure Available

Y
Salt Form

No
Molecular Formula

C₂₄H₂₃ClFN₅O₂
Molecular Weight

467.92
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>10 mg/ml)
Handling

Protect from air and light
Tag Line

A pan-ErbB tyrosine kinase inhibitor
Storage Condition

-20°C
Shipping Condition

Gel pack
Shelf Life

36 months
PubChem CID

6445562
PubChem CID Link
SMILES

CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
InChi

InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+
InChi Key

WVUNYSQLFKLYNI-AATRIKPKSA-N
Data Sheet Link
MSDS Available

Yes