Wortmannin, Penicillium funiculosum

Alternative_name

KY 12420
Description

Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC₅₀ = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC₅₀ = 5.8 nM).
CAS Number

19545-26-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₄O₈
Molecular Weight

428.44
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (50 mM) or EtOH (5 mM)
Handling

Protect from air and light
Tag Line

A PI3 Kinase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD00133927
PubChem CID

312145
PubChem CID Link
SMILES

CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
InChi

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
InChi Key

QDLHCMPXEPAAMD-QAIWCSMKSA-N
Data Sheet Link
MSDS Available

Yes