CTBP1 Antibody
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Catalog number3796-100
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PricePlease ask
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Size100 μl
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Antibody TargetCTBP1
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Target Alternative NameCTBP, CTBP1, CTBP-1, C-Terminal Binding Protein 1
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Antibody TypePolyclonal
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Species ReactivitiesHuman, mouse
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Immunogen SequenceSynthetic peptide of human CTBP1
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AccessionQ13363
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Gene Id1487
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AppearanceColorless liquid
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FormLiquid
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Formulation100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
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PurificationAffinity purified
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ApplicationWestern blot
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Application And UsagesWestern blotting (1:500 – 1:2000). However, the optimal concentrations should be determined individually. HeLa nuclear extract (Cat.# 1641-1) can be used as a positive control. The antibody recognizes the CTBP1 of human and mouse origins. Reactivity to other species has not been tested.
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DescriptionCtBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CtBP1 and the related protein CtBP2 are characterized as C-terminal binding protein of adenovirus E1A, and they preferentially associate with the E1A via a 5-amino acid motif, PLDLS, to repress E1A induced oncogenesis and cellular transformation. CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis. During skeletal and T-cell development, CtBP1 and CtBP2 associate with the PLDLSL domain of ∂EF1, a cellular zinc finger-homeodomain protein, and thereby enhances ∂EF1 induced transcriptional silencing. In addition, CtBP complexes with CtIP, a protein that recognizes distinctly different protein motifs from CtBP. CtIP binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. CtIP/CtBP binding to BRCA1 inhibits the transactivation of the p21 promoter, and it is critical for regulating p21 transcription in response to DNA damage.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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FACS VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCTBP1-DT, CTBP1, CTBP1-AS
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Short nameCTBP1 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameC-terminal binding protein 1 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetC-terminal binding protein 1, BARS, CTBP1 and IDBG-6522 and ENSG00000159692 and 1487, oxidoreductase activity, nuclei, Ctbp1 and IDBG-152845 and ENSMUSG00000037373 and 13016, CTBP1 and IDBG-643874 and ENSBTAG00000008480 and 513131
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Gene info
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Identity
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Gene
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Long gene nameCTBP1 divergent transcript
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Synonyms gene
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Synonyms gene name
- chromosome 4 open reading frame 42
- CTBP1 antisense RNA 1 (head to head)
- CTBP1 antisense RNA 2 (head to head)
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Synonyms
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GenBank acession
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Locus
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Discovery year2007-12-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Divergent transcripts
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameC-terminal binding protein 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-08-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCTBP1 antisense RNA
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2013-06-14
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Antisense RNAs
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data