Bml 277 , CHK2 kinase inhibitor

• Catalog number
  SIH-436-50MG
• Price
  Please ask
• Size
  50 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  516480-79-8
• Description
  CHK2 kinase inhibitor
• Molecular weight
  363,8 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C20H14ClN3O2
• Origin
  Synthetic
• Purity pourcentage
  ≥98% (TLC)
• Soluble in
  Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml)
• Physical appearance
  Off-white solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  9969021
• Scientific context
  Bml 277 is a highly selective inhibitor of Chk2, making it a useful tool for dissecting the role of Chk2 in cellular signaling.
• Bibliography
  1. Pereg Y., et al. (2006) Mol. Cell Biol. 26(18): 6819–6831.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of BML 277 (SIH-436), a CHK2 kinase inhibitor. CAS #: 516480-79-8. Molecular Formula: C20H14ClN3O2. Molecular Weight: 363.8 g/mol. Chemical structure of BML 277 , a CHK2 kinase inhibitor (SIH-436). CAS # 516480-79-8. Molecular Formula: C20H14ClN3O2.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.05
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Bml   277   CHK2   kinase   inhibitor  
• Gene symbol
  CHEK2
• Short name
  Bml 277 , CHK2 kinase inhibitor
• Alternative name
  Bml 277 , CHK2 phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:16627
• Gene
  CHEK2
• Long gene name
  checkpoint kinase 2
• Synonyms gene
  • RAD53
• Synonyms gene name
  • CHK2 (checkpoint, S.pombe) homolog
  • CHK2 checkpoint homolog (S. pombe)
• Synonyms
  • CDS1
  • CHK2
  • HuCds1
  • PP1425
  • bA444G7
• GenBank acession
  • AF086904
• Locus
  22q12.1
• Discovery year
  2001-09-19
• Entrez gene record
  11200
• Pubmed identfication
  • 9836640
  • 10097108
• RefSeq identity
  • NM_001005735
• VEGA ID
  OTTHUMG00000151023
• Locus Specific Databases
  • LRG_302

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