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WP1066 for cell activation

WP1066 for cell activation is available 0 time from Biovision labs

Description A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.
Peptide sequence N/A
CAS number 857064-38-1
Molecular weight 356.22
Category Biochemicals
Other name (2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Molecular formula C₁₇H₁₄BrN₃O
Physical appearance Off-white solid
Supplied with N/A
Is this a salt? No
Is it cell-permeable? Yes
Purification ≥97% by HPLC
Reconstitute instructions DMSO (10 mg/ml) and Ethanol (5 mg/ml)
Storage condition -20°C
Shipping condition gel pack
Maximum time for storage 24 months
Storage instructions Protect from air and light
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetWP1066 for activation
Short name WP1066 for activation
Technique activation
Alternative name WP1066 to measure cellular activation
Tissue cell
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WP1066 for cell activation -
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • WP1066
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  • activation
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