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Human CellExp CXADR CAR human recombinant

Human CellExp CXADR CAR human recombinant is available 4 times from Biovision labs

7441-10 | Human CellExp CXADR /CAR, human recombinant size: 10 μg | 388.84 USD

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7441-50 | Human CellExp CXADR /CAR, human recombinant size: 50 μg | 877.83 USD

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7441-50 | Human CellExp™ CXADR /CAR, human recombinant size: 50 μg | 821.28 USD

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7441-10 | Human CellExp™ CXADR /CAR, human recombinant size: 10 μg | 289.86 USD

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Synonyms CXADR, CAR, CAR4/6, HCAR
Alternates names CXADR, CAR, CAR4/6, HCAR
Taglines A homophilic and as a heterophilic cell adhesion molecule
Biomolecule/Target CXADR /CAR
NCBI Gene ID #. 1525
NCBI Gene Symbol CXADR
Gene Source Human
Accession # P78310
Recombinant Yes
Source HEK293 cells
Purity N/A
Activity (Specifications/test method) N/A
Biological activity Measured by the ability of the immobilized protein to support the adhesion of mouse neutrophils. When 50000 cells/well are added to CXADR coated plates (4 μg/mL and 100 μL/well), approximately 20% - 50% will adhere specifically after 60 minutes at 37℃.
Results Measured by the ability of the immobilized protein to support the adhesion of mouse neutrophils. When 50000 cells/well are added to CXADR coated plates (4 μg/mL and 100 μL/well), approximately 20% - 50% will adhere specifically after 60 minutes at 37℃.
Molecular Weight This protein is fused with a C-terminal 6×His tag, has a calculated MW of 24.9 kDa expressed. The predicted N-terminus is Leu 20. Protein migrates as 35 kDa in reduced SDS-PAGE due to glycosylation.
Storage Temp. -20°C
Shipping Gel Pack
Shelf Life 1 year
Concentration N/A
Appearance Lyophilized
Physical form description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Usage For Research Use Only! Not to be used in humans
Target CXADR /CAR
Background Coxsackie virus and adenovirus receptor (CXADR) also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V­ type (D1) and a C2­ type (D2) Ig­like domain, a transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.
Molecular weight This protein is fused with a C-terminal 6×His tag, has a calculated MW of 24.9 kDa expressed. The predicted N-terminus is Leu 20. Protein migrates as 35 kDa in reduced SDS-PAGE due to glycosylation.
Synonym CXADR, CAR, CAR4/6, HCAR
Other name CXADR, CAR, CAR4/6, HCAR
NCBI gene number 1525
NCBI gene CXADR
Gene source Human
NCBI number P78310
Purification ≥95%
Tested applications SDS-PAGE, N/A
Tested activity N/A
Reesults Measured by the ability of the immobilized protein to support the adhesion of mouse neutrophils. When 50000 cells/well are added to CXADR coated plates (4 μg/mL and 100 μL/well), approximately 20% - 50% will adhere specifically after 60 minutes at 37℃.
Binding ability N/A
Unit N/A
Storage condition -20°C
Shipping under Gel Pack
Physical appearance Lyophilized
Physical properties Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
How to reconstitute Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Aa sequence N/A
Before use Centrifuge the vial prior to opening.
Notes For Research Use Only! Not to be used in humans
Properties Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source Recombinants or rec. proteins
Group recombinants
Technique Recombinant
Alternative technique rec
Alternative to gene target coxsackie virus and adenovirus receptor, CAR and CAR4/6 and HCAR, CXADR and IDBG-854 and ENSG00000154639 and 1525, connexin binding, nuclei, Gm1123 and IDBG-192613 and ENSMUSG00000044860 and 382097, CXADR and IDBG-630474 and ENSBTAG00000004869 and 281733
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