anti-HDAC5 (phospho Ser498) Antibody
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Catalog number
79-192
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Price
Please ask
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Size
0.1 mg
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Gene info
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
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Gene names
HD5, NY-CO-9, NFKB3, HD5
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Antibodie s label
unlabelled serum
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Purity
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
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Ab raised in
Rabbit
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Type
Polyclonal
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Spicific to
This antibody detects endogenous level of HDAC5 only when phosphorylated at serine498.
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Antigen
HDAC5 (Phospho-Ser498) antibody was made against a peptide sequence around phosphorylation site of serine 498 (T-Q-S (p) -S-P) derived from Human HDAC5/7.
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Immuno application
Western Blot, immuno-histo-chemistry
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Antibody advice
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
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Suspention pH azide
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Keep at
Store antibody at -20 grades C for up to one year.
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Works with
Human, Mouse, Rat
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Omim nr
62750349
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Ncbi nr
NP_001015053.1
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KDa
124 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
10014
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GENE symbol
HDAC5
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Antigene name
histone deacetylase 5
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Source
Homo sapiens
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Protein nr
Q9UQL6
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
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Gene target
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Gene symbol
HDAC5
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Short name
anti-HDAC5 (phospho Ser498) Antibody
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Technique
Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative name
Antibody toHDAC5 (phosphorilated Ser498) (antibody to-)
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Alternative technique
antibodies
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Alternative to gene target
histone deacetylase 5, HD5 and NY-CO-9, HDAC5 and IDBG-53295 and ENSG00000108840 and 10014, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac5 and IDBG-212520 and ENSMUSG00000008855 and 15184, HDAC5 and IDBG-640847 and ENSBTAG00000016254 and 504242
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Gene info
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Identity
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Gene
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Long gene name
histone deacetylase 5
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Synonyms
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GenBank acession
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Locus
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Discovery year
2000-11-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Histone deacetylases, class IIA
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VEGA ID
MeSH Data
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Name
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Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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