Mouse anti Prostaglandin-E2 receptor EP3

• Catalog number
  X1492M
• Price
  Please ask
• Size
  100 μg

• Category
  Primary Antibodies
• Long description
  Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. ItÕs wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. _x000B__x000B_PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP3 receptors are 365-425 amino acid proteins. There are currently 4 known isoforms of EP3 receptors named EP3A, 3B, 3C and 3D. Each of has different physiological function, but differ only in the carboxyl terminus and how they couple to their respective G-proteins. EP3 receptors are involved in water absorption, gastric acid secretion, uterine contraction, neurotransmitter release and the hydrolysis of fat cells (lipolysis). EP3 receptors also act as a mediator of neural inflammation. These receptors are mainly localized in the brain, kidney, stomach, uterus and ovaries.
• Antibody come from
  Synthetic peptide derived from the rat 1A calcium channel conjugated to KLH
• Other description
  Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
• Clone
  5F5
• Antigen antibody binding interaction
  Mouse anti Prostaglandin-E2 receptor EP3 Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Rat, Bovine, Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  This antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
• Storage
  -20ºC
• Relevant references
  1. Starr,T.V.B et.al 'Primary structure of a calcium channel that is highly expressed in the rat cerebellum' Proc. Natl. Acad. Sci. U.S.A. 88, 5621-5625 (1991) _x000B__x000B_2. Snutch,T.Pet.al 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990)_x000B__x000B_3. Yu,A.S et.al. 'Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney' Proc. Natl. Acad. Sci. U.S.A. 89 (21), 10494-10498 (1992)_x000B__x000B_4. Hansen PB, , et al.'Vascular smooth muscle cells express the alpha(1A) subunit of a P-/Q-type voltage-dependent Ca(2+)Channel, and It is functionally important in renal afferent arterioles.' Circ Res (United States) 87(10) p896-902 (2000)_x000B__x000B_5. Stephens,G.I. et.al 'The Cav2.1/alpha1A (P/Q-type) voltage-dependent calcium channel mediates inhibitory neurotransmission onto mouse cerebellar Purkinje cells.' Eur J Neurosci 13(10) 1902-12 (2001)
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  Prostaglandin-E2   receptor   EP3  
• Gene symbol
  DLAT, DBT, SNORA62, UBE2S, DLST, UBE2O, NFE2, CST12P, SDR16C5, CDC34
• Short name
  Mouse anti Prostaglandin-E2 receptor EP3
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG2a
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to Prostaglandin-E2 receptor EP3
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:2896
• Gene
  DLAT
• Long gene name
  dihydrolipoamide S-acetyltransferase
• Synonyms gene
  • DLTA
• Synonyms
  • PDC-E2
  • E2
• Synonyms name
  • E2 component of pyruvate dehydrogenase complex
  • dihydrolipoyllysine-residue acetyltransferase
• GenBank acession
  • Y00978
• Locus
  11q23.1
• Discovery year
  1989-06-30
• Entrez gene record
  1737
• Pubmed identfication
  • 8102256
• RefSeq identity
  • NM_001931
• Classification
  • Pyruvate dehydrogenase complex
• VEGA ID
  OTTHUMG00000133751

Gene info

• Identity
  HGNC:2698
• Gene
  DBT
• Long gene name
  dihydrolipoamide branched chain transacylase E2
• Synonyms gene name
  • dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease)
• Synonyms
  • BCOADC-E2
  • BCKAD-E2
  • BCKDH-E2
• Synonyms name
  • dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
  • lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
  • branched chain 2-oxo-acid dehydrogenase complex component E2
• GenBank acession
  • BC016675
• Locus
  1p21.2
• Discovery year
  1989-06-30
• Entrez gene record
  1629
• Pubmed identfication
  • 1420314
  • 1429740
• RefSeq identity
  • NM_001918
• VEGA ID
  OTTHUMG00000010921

Gene info

• Identity
  HGNC:10107
• Gene
  SNORA62
• Long gene name
  small nucleolar RNA, H/ACA box 62
• Synonyms gene
  • RNE2
  • RNU108
• Synonyms gene name
  • RNA, U108 small nucleolar
• Synonyms
  • E2
  • E2-1
• GenBank acession
  • L07383
  • L22739
• Locus
  3p22.1
• Discovery year
  1993-06-18
• Entrez gene record
  6044
• Pubmed identfication
  • 8421699
  • 8415643
  • 16381836
• RefSeq identity
  • NR_002324
• Classification
  • Small nucleolar RNAs, H/ACA box

Gene info

• Identity
  HGNC:17895
• Gene
  UBE2S
• Long gene name
  ubiquitin conjugating enzyme E2 S
• Synonyms gene name
  • ubiquitin-conjugating enzyme E2S
• Synonyms
  • E2-EPF
• Synonyms name
  • ubiquitin carrier protein
  • ubiquitin-conjugating enzyme E2-24 kD
  • ubiquitin-protein ligase
• GenBank acession
  • BC004236
• Locus
  19q13.42
• Discovery year
  2004-01-12
• Entrez gene record
  27338
• Pubmed identfication
  • 1379239
• RefSeq identity
  • NM_014501
• Classification
  • Ubiquitin conjugating enzymes E2
• VEGA ID
  OTTHUMG00000180811

Gene info

• Identity
  HGNC:2911
• Gene
  DLST
• Long gene name
  dihydrolipoamide S-succinyltransferase
• Synonyms gene
  • DLTS
• Synonyms gene name
  • dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
• Synonyms
  • OGDC-E2
  • KGD2
• Synonyms name
  • Dihydrolipoyllysine-residue succinyltransferase
  • 2-oxoglutarate dehydrogenase complex component E2
• Locus
  14q24.3
• Discovery year
  1989-06-30
• Entrez gene record
  1743
• Pubmed identfication
  • 8009371
• VEGA ID
  OTTHUMG00000171483

Gene info

• Identity
  HGNC:29554
• Gene
  UBE2O
• Long gene name
  ubiquitin conjugating enzyme E2 O
• Synonyms gene name
  • ubiquitin-conjugating enzyme E2O
• Synonyms
  • E2-230K
• GenBank acession
  • AB051521
• Locus
  17q25.1
• Discovery year
  2005-12-15
• Entrez gene record
  63893
• Pubmed identfication
  • 11311559
  • 11214970
• RefSeq identity
  • NM_022066
• VEGA ID
  OTTHUMG00000180178

Gene info

• Identity
  HGNC:7780
• Gene
  NFE2
• Long gene name
  nuclear factor, erythroid 2
• Synonyms gene name
  • nuclear factor (erythroid-derived 2), 45kD
  • nuclear factor (erythroid-derived 2), 45kDa
• Synonyms
  • NF-E2
• GenBank acession
  • BC005044
• Locus
  12q13.13
• Discovery year
  1993-11-03
• Entrez gene record
  4778
• Pubmed identfication
  • 8355703
• RefSeq identity
  • NM_006163
• Classification
  • Basic leucine zipper proteins
• VEGA ID
  OTTHUMG00000169761

Gene info

• Identity
  HGNC:31920
• Gene
  CST12P
• Long gene name
  cystatin 12, pseudogene
• Synonyms
  • Cst
  • E2
  • Ctes4
• Locus
  20p11.21
• Discovery year
  2012-08-14
• Pubmed identfication
  • 12700194
  • 20565543
• Classification
  • Cystatins, type 2
• VEGA ID
  OTTHUMG00000032072

Gene info

• Identity
  HGNC:30311
• Gene
  SDR16C5
• Long gene name
  short chain dehydrogenase/reductase family 16C member 5
• Synonyms gene name
  • short chain dehydrogenase/reductase family 16C, member 5
• Synonyms
  • RDHE2
  • RDH-E2
  • EPHD-2
• Synonyms name
  • Epidermal retinol dehydrogenase 2
• Locus
  8q12.1
• Discovery year
  2008-12-23
• Entrez gene record
  195814
• Pubmed identfication
  • 12372410
• RefSeq identity
  • NM_138969
• Classification
  • Short chain dehydrogenase/reductase superfamily
• VEGA ID
  OTTHUMG00000164311

Gene info

• Identity
  HGNC:1734
• Gene
  CDC34
• Long gene name
  cell division cycle 34, ubiqiutin conjugating enzyme
• Synonyms
  • E2-CDC34
  • UBE2R1
  • UBC3
• Synonyms name
  • ubiquitin conjugating enzyme E2 R1
• GenBank acession
  • L22005
• Locus
  19p13.3
• Discovery year
  1994-05-12
• Entrez gene record
  997
• Pubmed identfication
  • 8248134
  • 16210246
• RefSeq identity
  • NM_004359
• Classification
  • Ubiquitin conjugating enzymes E2
• VEGA ID
  OTTHUMG00000180558

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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