OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA)

Source

Protein conjugation
Predicted Molecular Mass KD

NA
Accurate Molecular Mass KD

NA
Organism species

Homo sapiens (Human)
Item Name

p53 Upregulated Modulator Of Apoptosis
Alternative Names

JFY1; BBC3; BCL2 Binding Component 3
Research Area

Apoptosis;Tumor immunity;
Buffer Formulation

PBS, pH7.4.
Traits

Freeze-dried powder
Purity

> 90%
Protein length

NA
Tag

No tag
Expression System

Protein Conjugation
Application

Immunogen; SDS-PAGE; WB
Manual link
Description

This 1 is suited for programmed cell-death studies.
Gene

Ovalbumin (abbreviated OVA) is the main protein found in egg white, making up 60-65% of the total protein. Ovalbumin displays sequence and three-dimensional homology to the serpin superfamily, but unlike most serpins it is not a serine protease inhibitor. The function of ovalbumin is unknown, although it is presumed to be a storage protein. OVA is also the best characterized and the first antigen proteins used as a transgene to make transgenic mice. Many different transgenic mouse models have systemic OVA expression driven by the ubiquitously expressed b-actin promoter or tissue-specific OVA expression with insulin promoter to drive the transgene expression, for studying type I diabetes, or in different isoforms, secreted or cell-membrane associated, and more recently as inducible transgene models. These C57BL/6 mice, BALB/c mice models are well characterized, and have contributed to our understanding of immunogenicity and tolerance by the OVA model.

Gene target

OVA Conjugated p53 Upregulated Modulator PUMA
Gene symbol

BBC3, HCAR2
Short name

OVA Conjugated p53 Upregulated Modulator Of Apoptosis (PUMA)
Technique

apoptosis, apoptosis pathway, antibody Conjugates
Host

chemical synthesis
Species

Homo sapiens (Human)
Alternative name

OVA coupled p53 Upregulated Modulator on programmed cellular destruction (PUMA)
Alternative technique

celldeath

Identity

HGNC:17868
Gene

BBC3
Long gene name

BCL2 binding component 3
Synonyms
- JFY1
- PUMA
Synonyms name
- p53-upregulated modulator of apoptosis
GenBank acession
- AF332558
Locus

19q13.32
Discovery year

2002-07-22
Entrez gene record

27113
Pubmed identfication
- 11463392
- 11572983
RefSeq identity
- NM_014417
Classification
- BCL2 homology region 3 (BH3) only
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000183489