CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor) (PE) Antibody

• Catalog number
  GEN602425
• Price
  Please ask
• Size
  100 Tests

• Also known as
  CD51/CD61 Integrin alphaV beta3
• Other names
  N/A
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  N/A
• Gene name synonims
  N/A
• Other gene names
  N/A
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1
• Clone
  4j22
• Host organism
  Mouse (Mus musculus)
• Source organism
  Human (Homo sapiens)
• Species reactivity
  Chicken, Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets. Species Cross Reactivity: Human, chicken. Does not crossreact with porcine, lapine or bovine tissue.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  Affinity Puriffied by Protein G affinity chromatography
• Form Appearance
  Supplied as a lyophilized powder in PBS, pH 7.2, 1.0% BSA, 0.1% sodium azide. Conjugated to R. Phycoerythrin (RPE). Reconstitute with 1ml sterile 40-50% glycerol, ddH2O.
• Concentration
  N/A
• Storage and shipping
  Lyophilized powder may be stored at Keep the antibody refrigerated at +4 degrees Celsius. Temperature variations in the range between +1C to +7C are tolerable. Reconstitute by adding ddH2O. Aliquot and Store the antibody at +4 degrees Celsius. DO NOT FREEZE! Reconstituted product is stable for 12 months as an undiluted liquid. Dilute only prior to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested applications
  Flow Cytometry (FC/FACS)
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• French translation
  anticorps

• Gene target
  CD51/CD61   Integrin   alphaV   beta3   RGD-dependent   Vitronectin   Receptor  
• Gene symbol
  ITGB3, ITGAV
• Short name
  CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor) (PE) Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Label
  PE
• Alternative name
  Anti-CD51/CD61 Integrin alphaV beta3 (RGD-dependent Vitronectin Receptor) (PE)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6156
• Gene
  ITGB3
• Long gene name
  integrin subunit beta 3
• Synonyms gene
  • GP3A
• Synonyms gene name
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
• Synonyms
  • CD61
  • GPIIIa
• Synonyms name
  • platelet glycoprotein IIIa
  • antigen CD61
• Locus
  17q21.32
• Discovery year
  1988-06-09
• Entrez gene record
  3690
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_000212
• Classification
  • CD molecules
  • Integrin beta subunits
• VEGA ID
  OTTHUMG00000171956
• Locus Specific Databases
  • LRG_481

Gene info

• Identity
  HGNC:6150
• Gene
  ITGAV
• Long gene name
  integrin subunit alpha V
• Synonyms gene
  • VNRA
  • MSK8
  • VTNR
• Synonyms gene name
  • antigen identified by monoclonal antibody L230
  • vitronectin receptor
  • integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
  • integrin, alpha V
• Synonyms
  • CD51
• Locus
  2q32.1
• Discovery year
  1988-07-19
• Entrez gene record
  3685
• Pubmed identfication
  • 2454952
• RefSeq identity
  • NM_002210
• Classification
  • CD molecules
  • Integrin alpha subunits
• VEGA ID
  OTTHUMG00000132635

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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