EPZ-6438

• Catalog number
  2383-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; E-7438
• Description
  A potent and selective inhibitor of histone methyltransferase EZH2. EPZ-6438 specifically inhibits cellular H3K27 methylation leading to selective apoptotic killing of SMARCB1 mutant MRT cells. It also induces neuronal differentiation and cell cycle inhibition while suppressing expression of Hedgehog (Hh) pathway genes.
• CAS Number
  1403254-99-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₄H₄₄N₄O₄
• Molecular Weight
  572.74
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml)
• Handling
  Protect from light and air
• Tag Line
  A potent EZH2 inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• SMILES
  CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCOCC4)C=C3)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C2C
• InChi
  InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
• InChi Key
  NSQSAUGJQHDYNO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  EPZ-6438  
• Short name
  EPZ-6438
• Alternative name
  EPZ-6438

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