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Antibody Target
TGF-b3
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Target Alternative Name
TGF-b3, TGF b3,TGF-beta3, TGF beta-3, TGFbeta, TGFb3, transforming growth factor beta 3
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Antibody Type
Polyclonal
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Species Reactivities
Human, mouse, rat
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Immunogen Sequence
Synthetic peptide surrounding amino acid 254of human TGF-β3
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Accession
CAA33024
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Gene Id
7043
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Appearance
Colorless liquid
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Form
Liquid
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Concentration
0.5 mg/ml
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Formulation
0.5 mg/ml peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
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Purification
Affinity purified
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Application
Western blot
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Application And Usages
Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes~25 kDa TGF-β3 from samples of human, mouse, and rat origins. Reactivity to other species has not been tested.
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Description
The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal throμgh the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.
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Storage Condition
-20 °C
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Shipping Condition
gel pack
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Shelf Life
12 months
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Usage
For Research Use Only! Not to be used in humans.
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Handling
The antibody solution should be gently mixed before use.
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Western Blot Verified
Verified
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Immunocytochemistry Verified
Not Verified
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Immunofluorescence Verified
Not Verified
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Immunoprecipitation Verified
Not Verified
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FACS Verified
Not Verified
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ELISA Verified
Not Verified
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ChIP Verified
Not Verified
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Flow Cytometry Verified
Not Verified
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Properties
If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
