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CHK2 Thr68 Antibody ALEXA FLUOR

CHK2 Thr68 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-3721R-A350 | CHK2 (Thr68) Antibody, ALEXA FLUOR 350 size: 100ul | 408.10 USD

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bs-3721R-A488 | CHK2 (Thr68) Antibody, ALEXA FLUOR 488 size: 100ul | 408.10 USD

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bs-3721R-A555 | CHK2 (Thr68) Antibody, ALEXA FLUOR 555 size: 100ul | 408.10 USD

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bs-3721R-A594 | CHK2 (Thr68) Antibody, ALEXA FLUOR 594 size: 100ul | 408.10 USD

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bs-3721R-A647 | CHK2 (Thr68) Antibody, ALEXA FLUOR 647 size: 100ul | 408.10 USD

Catalog number bs-3721R-A647
Price 408.10 USD
Size 100ul
Long name CHK2 (Thr68) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
Also known as Anti-CHK2 Thr68 PAb ALEXA FLUOR 647
Conjugated with ALEXA FLUOR® 647
Excitation emission 650nm/665nm
Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-CHK2 Thr68 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR 647
French translation anticorps
Label ALEXA FLUOR 647
Alternative name CHK2 (Thr68) Polyclonal Antibody, ALEXA FLUOR 647
1. Gene info
Identity 16627
Gene CHEK2
Long gene name checkpoint kinase 2
Synonyms gene
  • RAD53
Synonyms gene name
  • CHK2 (checkpoint, S.pombe) homolog
  • CHK2 checkpoint homolog (S. pombe)
Synonyms
  • CDS1
  • CHK2
  • HuCds1
  • PP1425
  • bA444G7
GenBank acession
  • AF086904
Locus 22q12.1
Discovery year 2001-09-19
Entrez gene record 11200
Pubmed identfication
  • 9836640
  • 10097108
RefSeq identity
  • NM_001005735
Havana BLAST/BLAT OTTHUMG00000151023
Locus Specific Databases
  • LRG_302
Product images
    #.png#bs#.jpgFormalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-Phospho-CHK2 (Thr68) Polyclonal Antibody, Unconjugated (bs-3721R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\\nL1 rat brain lysates, L2 human colon carcinoma lysates probed with Anti- Phospho-CHK2(Thr68) Polyclonal Antibody, Unconjugated (bs-3721R) at 1:200 in 4?C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37?C. Predicted
Product files
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen CHK2 Thr68
Specificity This is a highly specific antibody against CHK2 Thr68.
Modification Phosphorylation
Modification Site Thr68
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen range 50-90/543
Subcellular location Nucleus
Source KLH conjugated synthetic phosphopeptide derived from human CHK2 around the phosphorylation site of Thr68
Gene ID Number 11200
Swiss Prot O96017
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Crossreactivity Human, Mouse, Rat
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.
Purification Purified by Protein A.
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Checkpoint kinase 2; CHEK2
Gene targetCHK2 Thr68
Short name Anti-CHK2 Thr68
Technique Antibody
Isotype Immunoglobulin G (IgG)
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Anti-CHK2 Thr68 | Technique alternative | 01011200491
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