DDIT3 Polyclonal Antibody
-
Catalog number
CAC07500
-
Price
Please ask
-
Size
100 μg
-
-
Other name
DNA damage-inducible transcript 3 protein,DDIT-3,C/EBP zeta,C/EBP-homologous protein,CHOP,C/EBP-homologous protein 10,CHOP-10,CCAAT/enhancer-binding protein homologous protein,Growth arrest and DNA damage-inducible protein GADD153,DDIT3,CHOP,CHOP10,GADD153
-
Immunogen
Recombinant human DNA damage-inducible transcript 3 protein (1-169AA)
-
Verified reactivity
Human
-
Verified applications
ELISA,IHC. Recommended dilution:IHC:1:20-1:200
-
Raised in
Rabbit
-
Clonality
Polyclonal
-
Protein number
P35638
-
Gene number
Please refer to GenBank
-
NCBI number
Please refer to NCBI
-
Purity
Protein G purified, >95%
-
Storage recommendation
Aliquot and store at -20°C. Minimize freezing and thawing.
-
Use before
1 year
-
Shipping requirements
Blue ice
-
Estimated production time
3-7 business days
-
Supplementary information
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
-
Notes
For research use only. Not for diagnostic procedures.
-
-
Properties
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
Group
Polyclonals and antibodies
-
About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
-
French translation
anticorps
-
Gene target
-
Gene symbol
DDIT3
-
Short name
DDIT3 Polyclonal Antibody
-
Technique
Polyclonal, Antibody, antibodies against human proteins, antibodies for, Polyclonal antibodies (pAbs) are mostly rabbit or goat antibodies that are secreted by different B cells, whereas monoclonal antibodies come from a single N cell lineage. Pabs are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope.
-
Label
Unconjugated
-
Alternative name
Desoxyribonucleic acid-damage-inducible transcript 3 polyclonal (antibody to-)
-
Alternative technique
polyclonals, antibodies
-
Alternative to gene target
DNA-damage-inducible transcript 3, CEBPZ and CHOP and CHOP-10 and CHOP10 and GADD153, DDIT3 and IDBG-42805 and ENSG00000175197 and 1649, sequence-specific DNA binding, nuclei, Ddit3 and IDBG-194880 and ENSMUSG00000025408 and 13198, DDIT3 and IDBG-635159 and ENSBTAG00000031544 and 777788
-
Gene info
MeSH Data
-
Name
-
Concept
Scope note:
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Similar products