DRAM Antibody (NT)
-
Catalog number5075-100
-
PricePlease ask
-
Size100 µg
-
-
Antibody TargetDRAM
-
Target Alternative NameDamage-regulated autophagy modulator
-
Antibody TypePolyclonal
-
Species ReactivitiesHuman, mouse, rat
-
Immunogen SequenceDRAM antibody was raised against a 16 amino acid peptide from near the amino terminus of human DRAM.
-
AccessionQ8N682
-
Gene Id55332
-
AppearanceColorless liquid
-
FormLiquid
-
Concentration1 mg/ml
-
Formulation100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
-
PurificationAffinity chromatography purified via peptide column.
-
ApplicationWestern blot, Immunohistochemistry, ELISA
-
Positive ControlWestern Blot: K562 cell lysate Immunohistochemistry: Human liver tissue
-
Application And UsagesWestern Blot: 0.5-2 μg/ml, Immunohistochemistry: 2.5 μg/ml, ELISA. However, the optimal conditions should be determined individually.
-
DescriptionDamage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been sμggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and sμggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
-
Storage Condition-20 °C
-
Shipping Conditiongel pack
-
Shelf Life12 months
-
UsageFor Research Use Only! Not to be used in humans.
-
HandlingThe antibody solution should be gently mixed before use.
-
Western Blot VerifiedVerified
-
Immunocytochemistry VerifiedVerified
-
Immunofluorescence VerifiedNot Verified
-
Immunoprecipitation VerifiedNot Verified
-
FACS VerifiedNot Verified
-
ELISA VerifiedVerified
-
ChIP VerifiedNot Verified
-
Flow Cytometry VerifiedNot Verified
-
PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
-
French translationanticorps
-
Gene target
-
Gene symbolDRAM1
-
Short nameDRAM Antibody (NT)
-
TechniqueAntibody, antibodies against human proteins, antibodies for
-
IsotypeRabbit IgG1
-
Alternative nameDRAM (antibody to-) (NT)
-
Alternative techniqueantibodies
-
Gene info
-
Identity
-
Gene
-
Long gene nameDNA damage regulated autophagy modulator 1
-
Synonyms gene name
- DNA-damage regulated autophagy modulator 1
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2009-06-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data