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EPZ 5676 for cell activation

EPZ 5676 for cell activation is available 2 times from Biovision labs

2382-1 | EPZ-5676 for cell activation size: 1 mg | 213.34 USD

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2382-5 | EPZ-5676 for cell activation size: 5 mg | 674.44 USD

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Other name (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol
Supplied with N/A
Description A potent and selective inhibitor of DOT1L methyltransferase (Ki = 80 pM). EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations.
Category Biochemicals
Molecular formula C₃₀H₄₂N₈O₃
Is it cell-permeable? Yes
Molecular weight 562.71
Storage condition -20 ̊C
Shipping condition gel pack
Purification ≥98% by HPLC
Peptide sequence N/A
Is this a salt? No
CAS number 1380288-87-8
Storage instructions Protect from light and air
Maximum time for storage 36 months
Physical appearance Crystalline solid
Reconstitute instructions DMSO (~ 25 mg/ml)
Additional description For cells, cell lines and tissues in culture till half confluency.
Gene targetEPZ-5676 for activation
Short name EPZ-5676 for activation
Technique activation
Alternative name EPZ-5676 to measure cellular activation
Tissue cell
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