Recombinant Human BMP Receptor IA/ALK-3/CD292 (C-Fc-6His)

• Catalog number
  CD59-10
• Price
  Please ask
• Size
  10 ug

• Description
  Recombinant Human BMP receptor IA is produced by our Mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a Fc, 6His tag at the C-terminus.
• Species reactivity
  Human
• Origin
  Human cells
• Peptide sequence
  QNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
• Estimated molecular weight
  42,1 kDa
• Protein purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin level
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Shipping condition
  Ambient/Room Temperature
• Package form
  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
• Storage conditions
  Lyophilized protein should be stored at below -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at below -20°C for 3 months.
• Reconstitution conditions
  See included datasheet or contact us for more information.
• UniProt number
  P36894
• Other related products
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  BMP   Receptor   IA/ALK-3/CD292   C-Fc-6His  
• Gene symbol
  BMPR1A, GDF11, ALK, GDF10, BMPR2, ENPP7, GDF2, BMP1, MIR1302-3
• Short name
  Recombinant BMP Receptor IA/ALK-3/CD292 (C-Fc-6His)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. novo advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Human BMP receptor IA/ALK-3/CD292(C-Fc-6His)
• Alternative technique
  rec
• Alternative to gene target
  anaplastic lymphoma receptor tyrosine kinase, CD246 and NBLST3, ALK and IDBG-42084 and ENSG00000171094 and 238, transferase activity, Plasma membranes, Alk and IDBG-197259 and ENSMUSG00000055471 and 11682, ALK and IDBG-636042 and ENSBTAG00000007379 and 536642

Gene info

• Identity
  HGNC:1076
• Gene
  BMPR1A
• Long gene name
  bone morphogenetic protein receptor type 1A
• Synonyms gene
  • ACVRLK3
• Synonyms gene name
  • bone morphogenetic protein receptor, type IA
• Synonyms
  • ALK3
  • CD292
• GenBank acession
  • BC028383
• Locus
  10q23.2
• Discovery year
  1994-12-12
• Entrez gene record
  657
• Pubmed identfication
  • 8397373
  • 9730621
• RefSeq identity
  • NM_004329
• Classification
  • Type 1 receptor serine/threonine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000018657
• Locus Specific Databases
  • LRG_298

Gene info

• Identity
  HGNC:4216
• Gene
  GDF11
• Long gene name
  growth differentiation factor 11
• Synonyms
  • BMP-11
  • BMP11
• GenBank acession
  • AF100907
• Locus
  12q13.2
• Discovery year
  1999-12-02
• Entrez gene record
  10220
• Pubmed identfication
  • 15988002
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000170188

Gene info

• Identity
  HGNC:427
• Gene
  ALK
• Long gene name
  ALK receptor tyrosine kinase
• Synonyms gene name
  • anaplastic lymphoma kinase (Ki-1)
  • anaplastic lymphoma receptor tyrosine kinase
• Synonyms
  • CD246
  • ALK1
• GenBank acession
  • D45915
• Locus
  2p23.2-p23.1
• Discovery year
  1993-08-24
• Entrez gene record
  238
• Pubmed identfication
  • 8122112
• RefSeq identity
  • NM_004304
• Classification
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000152034
• Locus Specific Databases
  • LRG_488

Gene info

• Identity
  HGNC:4215
• Gene
  GDF10
• Long gene name
  growth differentiation factor 10
• Synonyms
  • BMP-3b
• GenBank acession
  • L42113
• Locus
  10q11.22
• Discovery year
  1997-09-12
• Entrez gene record
  2662
• Pubmed identfication
  • 8679252
• RefSeq identity
  • NM_004962
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000188319

Gene info

• Identity
  HGNC:1078
• Gene
  BMPR2
• Long gene name
  bone morphogenetic protein receptor type 2
• Synonyms gene
  • PPH1
• Synonyms gene name
  • primary pulmonary hypertension 1
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • bone morphogenetic protein receptor type II
• Synonyms
  • BRK-3
  • T-ALK
  • BMPR3
  • BMPR-II
• GenBank acession
  • Z48923
• Locus
  2q33.1-q33.2
• Discovery year
  1997-03-19
• Entrez gene record
  659
• Pubmed identfication
  • 7791754
• RefSeq identity
  • NM_001204
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000133617
• Locus Specific Databases
  • LRG_712

Gene info

• Identity
  HGNC:23764
• Gene
  ENPP7
• Long gene name
  ectonucleotide pyrophosphatase/phosphodiesterase 7
• Synonyms
  • alk-SMase
  • NPP7
• Synonyms name
  • alkaline sphingomyelinase
• GenBank acession
  • AY230663
• Locus
  17q25.3
• Discovery year
  2004-04-29
• Entrez gene record
  339221
• Pubmed identfication
  • 12885774
• RefSeq identity
  • NM_178543
• Classification
  • Ectonucleotide pyrophosphatase/phosphodiesterase family
• VEGA ID
  OTTHUMG00000177462

Gene info

• Identity
  HGNC:4217
• Gene
  GDF2
• Long gene name
  growth differentiation factor 2
• Synonyms
  • BMP-9
  • BMP9
• GenBank acession
  • AF156891
• Locus
  10q11.22
• Discovery year
  1997-09-12
• Entrez gene record
  2658
• Pubmed identfication
  • 10849432
• RefSeq identity
  • NM_016204
• Classification
  • Transforming growth factor beta superfamily
• VEGA ID
  OTTHUMG00000188320

Gene info

• Identity
  HGNC:1067
• Gene
  BMP1
• Long gene name
  bone morphogenetic protein 1
• Synonyms gene
  • PCOLC
• Synonyms gene name
  • procollagen C-endopeptidase
• Synonyms
  • BMP-1
• Synonyms name
  • procollagen C-endopeptidase
  • tolloid-like
• Locus
  8p21.3
• Discovery year
  1990-06-11
• Entrez gene record
  649
• Pubmed identfication
  • 2004778
• RefSeq identity
  • NM_006132
• Classification
  • Bone morphogenetic proteins
  • Astacins
• VEGA ID
  OTTHUMG00000097761

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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