Tyrosine kinase inhibitor

Alternative_Names

NA
CAS

1021950-26-4
MWt

586.61
Formula

C31H31FN6O5
Solubility

DMSO: ≥ 46 mg/mL
Clinical_Information

No Development Reported
Pathway

Protein Tyrosine Kinase/RTK
Target

c-Met/HGFR
Datasheet
SDS
Description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Identity

HGNC:17853
Gene

IBTK
Long gene name

inhibitor of Bruton tyrosine kinase
Synonyms gene
- BTKI
Synonyms gene name
- Bruton agammaglobulinemia tyrosine kinase inhibitor
- inhibitor of Bruton agammaglobulinemia tyrosine kinase
Synonyms
- DKFZP564B116
- BTBD26
GenBank acession
- AF235049
Locus

6q14.1
Discovery year

2003-08-29
Entrez gene record

25998
Pubmed identfication
- 11577348
RefSeq identity
- NM_015525
Classification
- Ankyrin repeat domain containing
- BTB domain containing
VEGA ID

OTTHUMG00000015102

Identity

HGNC:31672
Gene

IBTKP1
Long gene name

inhibitor of Bruton tyrosine kinase pseudogene 1
Synonyms gene name
- IBTK pseudogene 1
- inhibitor of Bruton agammaglobulinemia tyrosine kinase pseudogene 1
Locus

18q12.3
Discovery year

2010-03-19
Entrez gene record

100127883